ArticleAlzheimer's research & therapy2018
Prospective associations between pulse pressure and cognitive performance in Chinese middle-aged and older population across a 5-year study period.
Article in Alzheimer's research & therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 66 citations in OpenAlex.
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- Intrinsic capacity and the risk of adverse health outcomes in older adults: a population-based study.BMC geriatrics · 2026Article
- Estimated pulse wave velocity and incident cognitive impairment risk in stroke patients: a longitudinal cohort study.BMC cardiovascular disorders · 2025Article
- Association between central obesity and ADL impairment among the middle-aged and elderly population in China based on CHARLS.Scientific reports · 2025Article
- Longitudinal Relationship Between Activities of Daily Living and Depression in Older Adults Based on Parallel Process Latent Growth Curve Model with Mediation.Healthcare (Basel, Switzerland) · 2025Article
- Obesity paradox in cognitive function: a longitudinal study of BMI and cognitive impairment in older adult Chinese population.Frontiers in aging neuroscience · 2025Article
- Higher Long-Term Visit-to-Visit Blood Pressure Variability Is Associated With Severe Cerebral Small Vessel Disease in the General Population.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- The effect of childhood family adversity on adulthood depression among Chinese older migrant workers: gender differences in the mediating role of social-ecological systems.BMC public health · 2024Article
- The Association Between Cardiometabolic Risk and Cognitive Function Among Older Americans and Chinese.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- A change in social participation affects cognitive function in middle-aged and older Chinese adults: analysis of a Chinese longitudinal study on aging (2011-2018).Frontiers in public health · 2024Article
- Frailty, cognitive impairment, and depressive symptoms in Chinese older adults: an eight-year multi-trajectory analysis.BMC geriatrics · 2023Article
- Association of social isolation and cognitive performance: a longitudinal study using a four-wave nationwide survey.BMC public health · 2023Article
- Pulse pressure trajectories predict brain microstructure in community-dwelling older adults: Associations with executive function and modification by APOE.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Cognitive Function Trajectories and Factors among Chinese Older Adults with Subjective Memory Decline: CHARLS Longitudinal Study Results (2011-2018).International journal of environmental research and public health · 2022Article
- Pulse Pressure Is Associated with Rapid Cognitive Decline over 4 Years: A Population-Based Cohort Study.Brain sciences · 2022Article
- The association between healthy aging index and trajectories of disability: a population-based cohort study.Aging clinical and experimental research · 2022Article
- Pulse pressure is associated with cognitive performance in Japanese non-demented population: a cross-sectional study.BMC neurology · 2022Article
- Joint developmental trajectories and temporal precedence of physical function decline and cognitive deterioration: A longitudinal population-based study.Frontiers in psychology · 2022Article
- Longitudinal Associations of Newly Diagnosed Prediabetes and Diabetes with Cognitive Function among Chinese Adults Aged 45 Years and Older.Journal of diabetes research · 2022Article
- High Estimated Glomerular Filtration Rate Is Associated With Worse Cognitive Performance in the Hypertensive Population: Results From the China H-Type Hypertension Registry Study.Frontiers in aging neuroscience · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSubstantial evidence indicates that the relationship between blood pressure (BP) measures and cognitive functioning is inconsistent, complex, and age-related. Pulse pressure (PP), which can not only reflect arterial stiffness and but also represent the chronic effects of hypertension other than BP itself, has been considered as a better predictor of cognitive impairment. However, evidence on the association of cognitive function with PP has not been investigated extensively. We examined this relationship in a longitudinal study based on the latent growth model (LGM).
methodsThis study was based on a nationally representative sample of Chinese middle-aged and older participants from the China Health and Retirement Longitudinal Study (CHARLS), a prospective observational study conducted from 2011 to 2016. Cognitive performance was assessed on the basis of three measures of cognition. The PP was calculated as the difference of the average values of three systolic and diastolic BP readings. A series of potential confounders were collected in this research. The LGM was used to examine the effects of PP on cognitive performance at three time points. To test the independent effects of PP on the initial level and the subsequent development of cognition, unconditional and conditional models were compared sequentially.
resultsAfter excluding respondents with missing key variables, we ultimately included 9750 participants in the analysis. Cognitive performance scores and PP showed significant differences across time. After adjustment for the confounders, the standardized coefficients of PP in the LGM indicated negative effects on cognitive performance in elderly Chinese participants at wave 2 and wave 3 (P < 0.01). The initial level of PP in the unconditional model was negatively associated with the initial level (β = - 0.25) and the slope (β = - 0.16) of cognition, whereas these effects were attenuated and the association between intercept of PP and slope of cognition became nonsignificant after controlling for the confounders.
conclusionsThe implications of these results demonstrate that a higher PP lowers the cognitive performance of middle-aged and elderly persons independent of a comprehensive set of covariates, but it is not a contributor to the rate of change in cognition.
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