ArticleBiomedical engineering online2018
Carotid DSA based CFD simulation in assessing the patient with asymptomatic carotid stenosis: a preliminary study.
Article in Biomedical engineering online, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 25 citations in OpenAlex.
- A magnetic resonance imaging-based computational analysis of cerebral hemodynamics in patients with carotid artery stenosis.Quantitative imaging in medicine and surgery · 2023Article
- Reconstruction of carotid stenosis hemodynamics based on guidewire pressure data and computational modeling.Medical & biological engineering & computing · 2022Article
- Correlation between Carotid Stenosis Degree and Blood Pressure Variability in Patients with Carotid Stenosis.Computational and mathematical methods in medicine · 2022Article
- Assessment of turbulent blood flow and wall shear stress in aortic coarctation using image-based simulations.Biomedical engineering online · 2021Article
- Cerebral venous steal equation for intracranial segmental perfusion pressure predicts and quantifies reversible intracranial to extracranial flow diversion.Scientific reports · 2021Article
- The Rheology of the Carotid Sinus: A Path Toward Bioinspired Intervention.Frontiers in bioengineering and biotechnology · 2021Review
- Computational Fluid Simulation of Fibrinogen around Dental Implant Surfaces.International journal of molecular sciences · 2020Article
- Imaging modalities to diagnose carotid artery stenosis: progress and prospect.Biomedical engineering online · 2019Review
- Hydraulic conductivity and low-density lipoprotein transport of the venous graft wall in an arterial bypass.Biomedical engineering online · 2019Article
- Deregulated Long Non-Coding RNA HCG11 in Cerebral Atherosclerosis Serves as a Biomarker to Predict the Risk of Cerebrovascular Events.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
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8 authors at 3 institutions in 1 country.
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Abstract
backgroundCerebrovascular events are frequently associated with hemodynamic disturbance caused by internal carotid artery (ICA) stenosis. It is challenging to determine the ischemia-related carotid stenosis during the intervention only using digital subtracted angiography (DSA). Inspired by the performance of well-established FFRct technique in hemodynamic assessment of significant coronary stenosis, we introduced a pressure-based carotid arterial functional assessment (CAFA) index generated from computational fluid dynamic (CFD) simulation in DSA data, and investigated its feasibility in the assessment of hemodynamic disturbance preliminarily using pressure-wired measurement and arterial spin labeling (ASL) MRI as references.
methodsThe cerebral multi-delay multi-parametric ASL-MRI and carotid DSA including trans-stenotic pressure-wired measurement were implemented on a 65-year-old man with asymptomatic unilateral (left) ICA stenosis. A CFD simulation using simplified boundary condition was performed in DSA data to calculate the CAFA index. The cerebral blood flow (CBF) and arterial transit time (ATT) of ICA territories were acquired.
resultsCFD simulation showed good correlation (r = 0.839, P = 0.001) with slight systematic overestimation (mean difference - 0.007, standard deviation 0.017) compared with pressure-wired measurement. No significant difference was observed between them (P = 0.09). Though the narrowing degree of in the involved ICA was about 70%, the simulated and measured CAFA (0.942/0.937) revealed a functionally nonsignificant stenosis which was also verified by a compensatory final CBF (fronto-temporal/fronto-parietal region: 51.58/45.62 ml/100 g/min) and slightly prolonged ATT (1.23/1.4 s) in the involved territories, together with a normal left-right percentage difference (2.1-8.85%).
conclusionsThe DSA based CFD simulation showed good consistence with invasive approach and could be used as a cost-saving and efficient way to study the relationship between hemodynamic disorder caused by ICA stenosis and subsequent perfusion variations in brain. Further research should focus on the role of noninvasive pressure-based CAFA in screening asymptomatic ischemia-causing carotid stenosis.
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