ArticleThe Journal of international medical research2018
High serum uric acid levels are a protective factor against unfavourable neurological functional outcome in patients with ischaemic stroke.
Article in The Journal of international medical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Serum Uric Acid Levels and Outcome of Acute Ischemic Stroke: a Dose-Response Meta-analysis.Molecular neurobiology · 2024Pooled it
- Serum uric acid and prognosis in acute ischemic stroke: a dose-response meta-analysis of cohort studies.Frontiers in aging neuroscience · 2023Pooled it
- A Novel Nomogram Integrating Retinal Microvasculature and Clinical Indicators for Individualized Prediction of Early Neurological Deterioration in Single Subcortical Infarction.CNS neuroscience & therapeutics · 2025Observational
- [Association between serum uric acid and airflow obstruction based on the health-checkup population].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2024Article
- Association between the serum uric acid/serum creatinine ratio and cognitive function in older adults: NHANES in the United States.Scientific reports · 2024Article
- Sex difference in the associations among hyperuricemia with self-reported peptic ulcer disease in a large Taiwanese population study.Frontiers in medicine · 2024Article
- Article
- Serum uric acid to serum creatinine ratio predicts neurological deterioration in branch atheromatous disease.Frontiers in neurology · 2023Article
- Moderate hyperuricaemia ameliorated kidney damage in a low-renin model of experimental renal insufficiency.Basic & clinical pharmacology & toxicology · 2023Article
- A cross-sectional analysis of the relationship between ischemic stroke and uric acid in young people in highland areas.Frontiers in endocrinology · 2023Article
- J-Shaped Relationship of Serum Uric Acid with Unfavorable Short-Term Outcomes among Patients with Acute Ischemic Stroke.Biomedicines · 2022Article
- Relationship between hyperuricemia and serositis in patients with lupus nephritis.International urology and nephrology · 2022Article
- Uric Acid and Clinical Outcomes in Young Patients with Ischemic Stroke.Neuropsychiatric disease and treatment · 2022Article
- Higher uric acid is associated with better discharge recovery and short-term outcome in stroke patients treated with thrombolysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Hyperuricemia in Psoriatic Arthritis: Epidemiology, Pathophysiology, and Clinical Implications.Frontiers in medicine · 2021Review
- The Prognostic Value of Serum Uric Acid in Hospitalized Patients with Acute Cerebral Infarction.Disease markers · 2021Article
- Lower uric acid level may be associated with hemorrhagic transformation but not functional outcomes in patients with anterior circulation acute ischemic stroke undergoing endovascular thrombectomy.Metabolic brain disease · 2020Article
- Review
- Elevated plasma D-dimer levels are associated with short-term poor outcome in patients with acute ischemic stroke: a prospective, observational study.BMC neurology · 2019Observational
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective We aimed to evaluate the association between serum uric acid levels at the onset and prognostic outcome in patients with acute ischaemic stroke. Methods We retrospectively analysed the outcomes of 1166 patients with ischaemic stroke who were hospitalized in our centre during August 2008 to November 2012. Correlations of serum uric acid levels and prognostic outcomes were analysed. Results Men had higher serum uric acid levels and better neurological functional outcomes compared with women. There was a strong negative correlation between serum uric acid levels and unfavourable neurological functional outcomes. Generalized estimated equation analysis showed that a higher serum uric acid level (>237 µmol/L) was a protective factor for neurological functional outcome in male, but not female, patients. Among five trial of ORG 10172 in acute stroke treatment classification subtypes, only patients with the large-artery atherosclerosis subtype had a significant protective effect of serum uric acid levels on neurological outcome. Conclusions Our study shows that high serum uric acid levels are a significant protective factor in men and in the large-artery atherosclerosis subtype in patients with ischaemic stroke. This is helpful for determining the prognostic value of serum uric acid levels for neurological outcome of acute ischaemic stroke.
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