Evidence map›Paper›PMID 29529483›Full record

ArticleArchives of oral biology2018

The role of bone morphogenetic proteins 2 and 4 in mouse dentinogenesis.

Priyam Jani, Chao Liu, Hua Zhang, Khaled Younes, M Douglas Benson, Chunlin Qin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of oral biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Developmental Roles of FUSE Binding Protein 1 (International journal of molecular sciences · 2020
    Article
  8. Tooth Formation: Are the Hardest Tissues of Human Body Hard to Regenerate?International journal of molecular sciences · 2020
    Review
  9. Noggin inhibition of mouse dentinogenesis.Journal of oral biosciences · 2020
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Priyam JaniDepartment of Biomedical Sciences and Center for Craniofacial Research and Diagnosis, Texas A&M University College of Dentistry, Dallas, TX 75246, USA.
Chao LiuDepartment of Biomedical Sciences and Center for Craniofacial Research and Diagnosis, Texas A&M University College of Dentistry, Dallas, TX 75246, USA.
Hua ZhangDepartment of Biomedical Sciences and Center for Craniofacial Research and Diagnosis, Texas A&M University College of Dentistry, Dallas, TX 75246, USA.
Khaled YounesDepartment of Biomedical Sciences and Center for Craniofacial Research and Diagnosis, Texas A&M University College of Dentistry, Dallas, TX 75246, USA.
M Douglas BensonDepartment of Biomedical Sciences and Center for Craniofacial Research and Diagnosis, Texas A&M University College of Dentistry, Dallas, TX 75246, USA. Electronic address: mdbenson@tamhsc.edu.
Chunlin QinDepartment of Biomedical Sciences and Center for Craniofacial Research and Diagnosis, Texas A&M University College of Dentistry, Dallas, TX 75246, USA. Electronic address: cqin@tamhsc.edu.
Texas A&M University · US

Funding

The Roles of FAM20C (DMP4) in Odontogenesis and OsteogenesisR01DE022549 · NIDCR · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI QIN, CHUNLIN · 2013 to 2017
$1.8M
NIDCR NIH HHS R01 DE022549
6 · The paper itself

Abstract

objectiveThe bone morphogenetic proteins (BMPs) play crucial roles in tooth development. However, several BMPs retain expression in the dentin of the fully patterned and differentiated tooth. We hypothesized that BMP signaling therefore plays a role in the function of the differentiated odontoblast, the job of which is to lay down and mineralize the dentin matrix.

designWe generated mice deficient in Bmp2 and 4 using a dentin matrix protein 1 (Dmp1) promoter-driven cre recombinase that was expressed in differentiated odontoblasts.

resultsThe first and second molars of these Bmp2 and Bmp4 double conditional knockout (DcKO) mice displayed reduced dentin and enlarged pulp chambers compared to cre-negative littermate controls. DcKO mouse dentin in first molars was characterized by small, disorganized dentinal fibers, a wider predentin layer, and reduced expression of dentin sialophosphoprotein (DSPP), dentin matrix protein 1 (DMP1), and bone sialoprotein (BSP). DcKO mouse odontoblasts demonstrated increased type I collagen mRNA production, indicating that the loss of BMP signaling altered the rate of collagen gene expression in these cells. Bmp2 and Bmp4 single Dmp1-cre knockout mice displayed no discernable dentin phenotype.

conclusionsThese data demonstrate that BMP signaling in differentiated odontoblasts is necessary for proper dentin production in mature teeth.

Indexed as

Signal TransductionAnimalsBone Morphogenetic Protein 2Bone Morphogenetic Protein 4Cell DifferentiationCollagen Type ICollagen Type I, alpha 1 ChainDental Pulp CavityDentinDentinogenesisDentin SialophosphoproteinExtracellular Matrix ProteinsGene Expression Regulation, DevelopmentalIn Situ HybridizationIntegrin-Binding SialoproteinMiceBmp2 protein, mouseBmp4 protein, mouseBone Morphogenetic Protein 2Bone Morphogenetic Protein 4Collagen Type ICollagen Type I, alpha 1 ChainDentin SialophosphoproteinDmp1 protein, mouseExtracellular Matrix ProteinsIntegrin-Binding SialoproteinPhosphoproteinsSialoglycoproteinsBone morphogenetic protein 2Bone morphogenetic protein 4DentinOdontoblast

Identifiers

PMID29529483
PMCPMC5941946
OpenAlexW2791214902

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.