Evidence map›Paper›PMID 29529408›Full record

ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2018

Functional Activation During a Cognitive Control Task in Healthy Youth Specific to Externalizing or Internalizing Behaviors.

Katherine H Karlsgodt, Angelica A Bato, Toshikazu Ikuta, Bart D Peters, Pamela DeRosse, Philip R Szeszko, Anil K Malhotra

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Katherine H KarlsgodtDepartment of Psychology, University of California, Los Angeles, Los Angeles, California. Electronic address: karlsgodt@psych.ucla.edu.
Angelica A BatoFeinstein Institute for Medical Research, Manhasset, New York; Zucker Hillside Hospital, Glen Oaks, New York.
Toshikazu IkutaDepartment of Communication Sciences and Disorders, University of Mississippi, Oxford, Mississippi.
Bart D PetersZucker Hillside Hospital, Glen Oaks, New York.
Pamela DeRosseFeinstein Institute for Medical Research, Manhasset, New York; Zucker Hillside Hospital, Glen Oaks, New York; Northwell School of Medicine, Hempstead, New York.
Philip R SzeszkoJames J. Peters Veterans Affairs Medical Center, Bronx, New York; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York.
Anil K MalhotraFeinstein Institute for Medical Research, Manhasset, New York; Zucker Hillside Hospital, Glen Oaks, New York; Northwell School of Medicine, Hempstead, New York.
Feinstein Institute for Medical Research · USJames J. Peters VA Medical Center · USUniversity of California, Los Angeles · USUniversity of Mississippi · USZucker Hillside Hospital · US

Funding

Striatal D2/D3 Dopamine receptor availability in first episode schizophreniaP50MH080173 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI GREGERSEN, PETER K. · 2008 to 2012
$10.4M
Trials Operation Unit (OPERATIONS CORE)P30MH090590 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI CORRELL, CHRISTOPH U · 2010 to 2014
$7.9M
Multimodal Imaging of Executive and Reward Networks Across the Psychosis SpectrumR01MH101506 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KARLSGODT, KATHERINE HELEN · 2013 to 2017
$2.5M
Diffusion Tensor Imaging in First-Episode SchizophreniaR01MH076995 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI SZESZKO, PHILIP R · 2007 to 2010
$1.2M
The Genetics of Psychosis: Towards a Dimensional ApproachR00MH086756 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI DEROSSE, PAMELA · 2011 to 2013
$732k
NIMH NIH HHS P30 MH090590NIMH NIH HHS P50 MH080173NIMH NIH HHS R00 MH086756NIMH NIH HHS R01 MH076995NIMH NIH HHS R01 MH101506
6 · The paper itself

Abstract

backgroundExternalizing behaviors are negative behaviors expressed outwardly, including rule breaking, aggression, and risk taking; internalizing behaviors are expressed inwardly, including depression, withdrawal, and anxiety. Such behavior can cause problems in early life and predict difficulties across the lifespan. There is evidence for a relationship between executive function and both externalizing and internalizing. However, although these behaviors occur along a spectrum, there is little neuroimaging research on this relationship in typically developing youth.

methodsWe assessed 41 youth (10-19 years of age) using the Multi-Source Interference Task during functional magnetic resonance imaging and related the findings to self-reported externalizing and internalizing scores as measured by the Youth Self-Report. We performed a general linear model using FSL software; externalizing, internalizing, age, and sex were included in the model.

resultsCompared to the control condition, the more difficult Multi-Source Interference Task interference condition was associated with greater engagement of the frontoparietal cognitive control system and decreased engagement of regions in the default mode network, based on a cluster threshold of Z > 3.1 (p = .01). When we examined regions uniquely associated with either internalizing or externalizing, we found that within the same group of subjects, higher externalizing behavior was associated with hyperactivity in the parietal lobe; in contrast, higher internalizing behavior was associated with increased activation in the medial prefrontal cortex.

conclusionsThese findings suggest that externalizing and internalizing may be associated with altered, but different, patterns of activation during cognitive control. This has implications for our understanding of the relationship between cognitive control and behavioral problems in youth.

Indexed as

AdolescentAdolescent BehaviorAnxietyChildChild BehaviorChild Behavior DisordersDefense MechanismsDepressionFemaleHumansInternal-External ControlMaleRisk FactorsYoung AdultCognitive controlDevelopmentExecutive functionExternalizingFunctional MRIInternalizing

Identifiers

PMID29529408
PMCPMC5854198
OpenAlexW2755131983

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.