ArticleJournal of the American Chemical Society2018
Breaking the Base Barrier: An Electron-Deficient Palladium Catalyst Enables the Use of a Common Soluble Base in C-N Coupling.
Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Palladium-catalysed synthesis of small-molecule epigenetic inhibitors as anticancer therapeutics.Journal of enzyme inhibition and medicinal chemistry · 2026Review
- Nickel-catalyzed Chan-Lam coupling: an efficient route toRSC advances · 2025Article
- Pd-Catalyzed O-Arylation of Phenols Mediated by a Weak, Soluble Organic Base: Methodology, Mechanism, and Compatibility with Enabling Technologies.Journal of the American Chemical Society · 2025Article
- Rethinking carbanion chemistry from donor substituents to weakly coordinating carbanions.Nature reviews. Chemistry · 2025Review
- Catalyst Activation and Speciation Involving DyadPalladate Precatalysts in Suzuki-Miyaura and Buchwald-Hartwig Cross-Couplings.Organometallics · 2025Article
- Reductive Transamination of Pyridinium Salts to N-Aryl Piperidines.The Journal of organic chemistry · 2024Article
- A strategy for the controllable generation of organic superbases from benchtop-stable salts.Chemical science · 2024Article
- Unsymmetric N-heterocyclic carbene ligand enabled nickel-catalysed arylation of bulky primary and secondary amines.Chemical science · 2023Article
- Abiotic peptides as carriers of information for the encoding of small-molecule library synthesis.Science (New York, N.Y.) · 2023Article
- Emerging Trends in Cross-Coupling: Twelve-Electron-Based LChemical reviews · 2022Review
- Encapsulation Enhances the Catalytic Activity of C-N Coupling: Reaction Mechanism of a Cu(I)/Calix[8]arene Supramolecular Catalyst.ChemCatChem · 2022Article
- Palladium-Mediated Incorporation of Carboranes into Small Molecules, Peptides, and Proteins.Journal of the American Chemical Society · 2022Article
- Selective N-Arylation of p-Aminophenylalanine in Unprotected Peptides with Organometallic Palladium Reagents.Angewandte Chemie (International ed. in English) · 2021Article
- Aryl Amination Using Soluble Weak Base Enabled by a Water-Assisted Mechanism.Journal of the American Chemical Society · 2020Article
- Article
- Development of an Aryl Amination Catalyst with Broad Scope Guided by Consideration of Catalyst Stability.Journal of the American Chemical Society · 2020Article
- 2-Aminooxazole as a Novel Privileged Scaffold in Antitubercular Medicinal Chemistry.ACS medicinal chemistry letters · 2020Article
- An Improved PJournal of the American Chemical Society · 2020Article
- Palladium Complexes Based on Ylide-Functionalized Phosphines (YPhos): Broadly Applicable High-Performance Precatalysts for the Amination of Aryl Halides at Room Temperature.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Article
- Nickel-Catalyzed Decarbonylative Amination of Carboxylic Acid Esters.Journal of the American Chemical Society · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Due to the low intrinsic acidity of amines, palladium-catalyzed C-N cross-coupling has been plagued continuously by the necessity to employ strong, inorganic, or insoluble bases. To surmount the many practical obstacles associated with these reagents, we utilized a commercially available dialkyl triarylmonophosphine-supported palladium catalyst that facilitates a broad range of C-N coupling reactions in the presence of weak, soluble bases. The mild and general reaction conditions show extraordinary tolerance for even highly base-sensitive functional groups. Additionally, insightful heteronuclear NMR studies using
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.