ArticleBiochemistry2018
Tissue-like Neural Probes for Understanding and Modulating the Brain.
Article in Biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Molecular Mechanisms of Foreign Body Responses to Neural Electrodes and Surface Biofunctionalization Strategies for Interface Modulation.International journal of molecular sciences · 2026Review
- NongeneticACS nano · 2026Article
- Long-Term Stable Subdural Recordings Enabled by Fibrosis-Resistant Hydrogel-Integrated µECoG Arrays.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Development of a biocompatible 3D hydrogel scaffold using continuous liquid interface production for the delivery of cell therapies to treat recurrent glioblastoma.Bioengineering & translational medicine · 2024Article
- Stitching Flexible Electronics into the Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- A flexible neural implant with ultrathin substrate for low-invasive brain-computer interface applications.Microsystems & nanoengineering · 2022Article
- Nanowire-Enabled Bioelectronics.Nano today · 2021Article
- The Future of Neuroscience: Flexible and Wireless Implantable Neural Electronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Nanotechnology: new opportunities for the development of patch-clamps.Journal of nanobiotechnology · 2021Review
- How is flexible electronics advancing neuroscience research?Biomaterials · 2021Review
- Technological Challenges in the Development of Optogenetic Closed-Loop Therapy Approaches in Epilepsy and Related Network Disorders of the Brain.Micromachines · 2020Review
- Bioinspired Materials forMatter · 2020Article
- An Injectable Neural Stimulation Electrode Made from an In-Body Curing Polymer/Metal Composite.Advanced healthcare materials · 2019Article
- Stretchable and Fully Degradable Semiconductors for Transient Electronics.ACS central science · 2019Article
- The business of brain-computer interfaces.Nature biotechnology · 2019Article
- Precision electronic medicine in the brain.Nature biotechnology · 2019Review
- Article
- Advanced One- and Two-Dimensional Mesh Designs for Injectable Electronics.Nano letters · 2019Article
- Novel electrode technologies for neural recordings.Nature reviews. Neuroscience · 2019Review
- Multifunctional Freestanding Microprobes for Potential Biological Applications.Sensors (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Electrophysiology tools have contributed substantially to understanding brain function, yet the capabilities of conventional electrophysiology probes have remained limited in key ways because of large structural and mechanical mismatches with respect to neural tissue. In this Perspective, we discuss how the general goal of probe design in biochemistry, that the probe or label have a minimal impact on the properties and function of the system being studied, can be realized by minimizing structural, mechanical, and topological differences between neural probes and brain tissue, thus leading to a new paradigm of tissue-like mesh electronics. The unique properties and capabilities of the tissue-like mesh electronics as well as future opportunities are summarized. First, we discuss the design of an ultraflexible and open mesh structure of electronics that is tissue-like and can be delivered in the brain via minimally invasive syringe injection like molecular and macromolecular pharmaceuticals. Second, we describe the unprecedented tissue healing without chronic immune response that leads to seamless three-dimensional integration with a natural distribution of neurons and other key cells through these tissue-like probes. These unique characteristics lead to unmatched stable long-term, multiplexed mapping and modulation of neural circuits at the single-neuron level on a year time scale. Last, we offer insights on several exciting future directions for the tissue-like electronics paradigm that capitalize on their unique properties to explore biochemical interactions and signaling in a "natural" brain environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.