ArticleNucleic acids research2018
Single-target regulators form a minor group of transcription factors in Escherichia coli K-12.
Article in Nucleic acids research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 45 citations in OpenAlex.
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- Genomic SELEX Screening of Regulatory Targets of Transcription Factors.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Flexible gold standards for transcription factor regulatory interactions inFrontiers in genetics · 2024Article
- Expanded roles of lactate-sensing LldR in transcription regulation of theMicrobial genomics · 2023Article
- Metal-Responsive Transcription Factors Co-Regulate Anti-Sigma Factor (Rsd) and Ribosome Dimerization Factor Expression.International journal of molecular sciences · 2023Article
- About the dark corners in the gene function space of Escherichia coli remaining without illumination by scientific literature.Biology direct · 2023Article
- Genomic SELEX Reveals Pervasive Role of the Flagella Master Regulator FlhDC in Carbon Metabolism.International journal of molecular sciences · 2023Article
- Metabolically-targeted dCas9 expression in bacteria.Nucleic acids research · 2023Article
- Differential Impact of Hexuronate Regulators ExuR and UxuR on theInternational journal of molecular sciences · 2022Article
- Auxotrophic and prototrophic conditional genetic networks reveal the rewiring of transcription factors in Escherichia coli.Nature communications · 2022Article
- High Abundance of Transcription Regulators Compacts the Nucleoid in Escherichia coli.Journal of bacteriology · 2022Article
- Transcription Factor SrsR (YgfI) Is a Novel Regulator for the Stress-Response Genes in Stationary Phase inInternational journal of molecular sciences · 2022Article
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- Whole set of constitutive promoters for RpoN sigma factor and the regulatory role of its enhancer protein NtrC inMicrobial genomics · 2021Article
- Bacterial approaches to sensing and responding to respiration and respiration metabolites.Molecular microbiology · 2021Review
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The identification of regulatory targets of all TFs is critical for understanding the entire network of the genome regulation. The lac regulon of Escherichia coli K-12 W3110 is composed of the lacZYA operon and its repressor lacI gene, and has long been recognized as the seminal model of transcription regulation in bacteria with only one highly preferred target. After the Genomic SELEX screening in vitro of more than 200 transcription factors (TFs) from E. coli K-12, however, we found that most TFs regulate multiple target genes. With respect to the number of regulatory targets, a total of these 200 E. coli TFs form a hierarchy ranging from a single target to as many as 1000 targets. Here we focus a total of 13 single-target TFs, 9 known TFs (BetI, KdpE, LacI, MarR, NanR, RpiR, TorR, UlaR and UxuR) and 4 uncharacterized TFs (YagI, YbaO, YbiH and YeaM), altogether forming only a minor group of TFs in E. coli. These single-target TFs were classified into three groups based on their functional regulation.
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