ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2019
Development of a Dynamic Multi-Protein Signature of Postoperative Delirium.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Accumulating the key proteomic signatures associated with delirium: Evidence from systematic review.PloS one · 2024Pooled it
- Serum proteomic analysis in esophagectomy patients with postoperative delirium: A case-control study.Heart & lung : the journal of critical careTrial
- Mechanistic insights into postoperative delirium using untargeted high-throughput proteomics in elderly patients - a case-control study.Scientific reports · 2026Observational
- Complement Activation as a Predictor of Postoperative Delirium in Elderly Spine Surgery Patients.International journal of molecular sciences · 2026Article
- Long-chain polyunsaturated fatty acid lipid and oxylipin alterations in postoperative delirium after cardiac surgery.Journal of lipid research · 2026Article
- Natriuretic Peptides as a Predictor for Delirium After Cardiac Surgery: A Prospective Observational Study.Journal of clinical medicine · 2025Article
- Integrated Multi-Omics Analysis of Cerebrospinal Fluid in Postoperative Delirium.Biomolecules · 2024Article
- Evaluating Nutritional Risk Factors for Delirium in Intensive-Care-Unit Patients: Present Insights and Prospects for Future Research.Clinics and practice · 2023Review
- Age-dependent differences and similarities in the plasma proteomic signature of postoperative delirium.Scientific reports · 2023Article
- Recent advances in predicting, preventing, and managing postoperative delirium.Faculty reviews · 2023Review
- Application of Multiple Omics to Understand Postoperative Delirium Pathophysiology in Humans.Gerontology · 2023Review
- Biomarkers of delirium risk in older adults: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2023Review
- Article
- Proteome-Wide Analysis Using SOMAscan Identifies and Validates Chitinase-3-Like Protein 1 as a Risk and Disease Marker of Delirium Among Older Adults Undergoing Major Elective Surgery.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Preliminary Study of Serum Biomarkers Associated With Delirium After Major Cardiac Surgery.Journal of cardiothoracic and vascular anesthesia · 2022Article
- Development of a prediction model for mortality and cardiovascular outcomes in older adults taking into account AZGP1.Scientific reports · 2021Article
- Serum Proteomics of Older Patients Undergoing Major Cardiac Surgery: Identification of Biomarkers Associated With Postoperative Delirium.Frontiers in aging neuroscience · 2021Article
- Integrative Analysis of lncRNA and mRNA and Profiles in Postoperative Delirium Patients.Frontiers in aging neuroscience · 2021Article
- A New Severity Scoring Scale for the 3-Minute Confusion Assessment Method (3D-CAM).Journal of the American Geriatrics Society · 2020Article
- Evaluating Mechanisms of Postoperative Delirium and Cognitive Dysfunction Following Elective Spine Surgery in Elderly Patients (CONFESS): Protocol for a Prospective Observational Trial.JMIR research protocols · 2020Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Background: Delirium is common, morbid, and costly, yet its biology is poorly understood. We aimed to develop a multi-protein signature of delirium by identifying proteins associated with delirium from unbiased proteomics and combining them with delirium biomarkers identified in our prior work (interleukin [IL]-6 and IL-2). Methods: We used the Successful Aging after Elective Surgery (SAGES) Study of adults age ≥70 undergoing major noncardiac surgery (N = 560; 24% delirium). Plasma was collected preoperatively (PREOP) and on postoperative day 2 (POD2). In a nested matched case-control study involving 12 pairs of delirium cases and no-delirium controls, isobaric tags for relative and absolute quantitation-based (iTRAQ) mass spectrometry proteomics was applied to identify the top set of delirium-related proteins. With these proteins, we then conducted enzyme-linked immunosorbent assay (ELISA) confirmation, and if confirmed, ELISA validation in 75 matched pairs. Multi-marker conditional logistic regression was used to select the "best" PREOP and POD2 models for delirium. Results: We identified three proteins from iTRAQ: C-reactive protein (CRP), zinc alpha-2 glycoprotein (AZGP1), and alpha-1 antichymotrypsin (SERPINA3). The "best" multi-protein models of delirium included: PREOP: CRP and AZGP1 (Bayesian information criteria [BIC]: 93.82, c-statistic: 0.77); and POD2: IL-6, IL-2, and CRP (BIC: 87.11, c-statistic: 0.84). Conclusion: The signature of postoperative delirium is dynamic, with some proteins important before surgery (risk markers) and others at the time of delirium (disease markers). Our dynamic, multi-protein signature for delirium improves our understanding of delirium pathophysiology and may identify patients at-risk of this devastating disorder that threatens independence of older adults.
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