Evidence map›Paper›PMID 29529091›Full record

Trial reportPloS one2018

Effects of Ramadan fasting on aspirin resistance in type 2 diabetic patients.

Wahid Bouida, Kaouthar Beltaief, Houda Baccouche, Mouna Sassi, Zohra Dridi, Imen Trabelsi, Kamel Laaouiti, Taher Chakroun, Ilhem Hellara, Riadh Boukef and 7 more

Expression of concern Registry-linked trialOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. It is linked to trial NCT02720133 (Ramadan Fasting Effects in Patients With Cardiovascular Risk Factors), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02720133 completednot on this map

Ramadan Fasting Effects in Patients With Cardiovascular Risk Factors

Typeobservational_patient_registrySponsorUniversity of MonastirRan2013 to 2015Enrolled500ConditionsCardiovascular Risk Factors, FastingArmsbiochemical parameters
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Intermittent fasting and weight loss: Systematic review.Canadian family physician Medecin de famille canadien · 2020
    Pooled it
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Wahid BouidaEmergency Department, FattoumaBourguiba University Hospital, Monastir, Tunisia.
Kaouthar BeltaiefEmergency Department, FattoumaBourguiba University Hospital, Monastir, Tunisia.
Houda BaccoucheEmergency Department, FattoumaBourguiba University Hospital, Monastir, Tunisia.
Mouna SassiResearch Laboratory (LR12SP18) University of Monastir, Monastir, Tunisia.
Zohra DridiCardiology Department, FattoumaBourguiba University Hospital, Monastir, Tunisia.
Imen TrabelsiEmergency Department, FattoumaBourguiba University Hospital, Monastir, Tunisia.
Kamel LaaouitiEmergency Department, FattoumaBourguiba University Hospital, Monastir, Tunisia.
Taher ChakrounRegional blood transfusion center, FarhatHached University Hospital, Sousse, Tunisia.
Ilhem HellaraResearch Laboratory (LR12SP18) University of Monastir, Monastir, Tunisia.
Riadh BoukefResearch Laboratory (LR12SP18) University of Monastir, Monastir, Tunisia.
Nabil SaklyLaboratory of Immunology, FattoumaBourguiba University Hospital, Monastir Tunisia.
Mohsen HassineResearch Laboratory (LR12SP18) University of Monastir, Monastir, Tunisia.
Faouzi AddedResearch Laboratory (LR12SP18) University of Monastir, Monastir, Tunisia.
Rabie RazgallahMedis Laboratories, 1053, Tunis, Tunisia.
Fadhel NajjarBiochemistry Department, FattoumaBourguiba University Hospital, Monastir Tunisia.
Semir NouiraEmergency Department, FattoumaBourguiba University Hospital, Monastir, Tunisia.
Ramadan Research Group
Hospital Fatuma Bourguiba Monastir · TNUniversity of Monastir · TNHôpital Farhat Hached · TNHôpital Sahloul · TN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsRamadan fasting (RF) may affect aspirin resistance. We conducted this study in patients with cardiovascular risk (CVR) factors to assess the effect of RF on aspirin resistance and explore whether type 2 diabetes mellitus (DM) would influence this effect.

methodsA total of 177 stable patients with ≥2 CVR factors were recruited. All patients observed RF and were taking aspirin. Physical exam and standard biological tests including glycaemia and serum lipids data were performed before Ramadan (Pre-R), at the last week of Ramadan (R) and four weeks after the end of Ramadan (Post-R). In the same visits caloric intake was calculated and platelet reactivity to aspirin was assessed using Verify Now point-of-care assay.

resultsIn the overall population, there was no significant change in absolute aspirin reaction unit (ARU) values and in metabolic parameters. In DM patients (n = 127), ARU change from Pre-R values was+19.7 (p = 0.01) and +14.4 (p = 0.02) respectively at R and Post-R. During Ramadan, glycaemia, triglycerides, and cholesterol levels increased significantly and returned to Pre-R values thereafter. These changes were not observed in non-DM patients.

conclusionsDuring RF aspirin resistance increased only in DM patients. This effect persisted one month after Ramadan. Simultaneous alteration of glycemic control and increase of serum lipids levels could potentially be a favorable factor. STUDY REGISTRATION: The protocol was registered at clinicaltrials.gov under: NCT02720133.

Indexed as

FastingAgedAspirinBlood GlucoseBlood PlateletsCardiovascular DiseasesDiabetes Mellitus, Type 2Drug ResistanceFemaleHumansIslamMaleMiddle AgedPlatelet Aggregation InhibitorsRisk FactorsAspirinBlood GlucosePlatelet Aggregation Inhibitors

Identifiers

PMID29529091
PMCPMC5846719
OpenAlexW2791140729

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.