ArticlePLoS computational biology2018
Gap junction plasticity as a mechanism to regulate network-wide oscillations.
Article in PLoS computational biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Frequency-dependent coupling in response to oscillatory inputs in minimal networks of electrically coupled nodes: Gap junction networks and spatially extended neurons.Biological cybernetics · 2026Article
- Network hypermotifs in biological systems: structure, dynamics, and functional implications.NPJ systems biology and applications · 2026Review
- Photomapping electrically coupled networks of the mature thalamus and cortex.bioRxiv : the preprint server for biology · 2026Article
- Rethinking parvalbumin: From passive marker to active modulator of hippocampal circuits.IBRO neuroscience reports · 2025Article
- Whole brain functional connectivity: Insights from next generation neural mass modelling incorporating electrical synapses.PLoS computational biology · 2024Article
- Review
- Learning with sparse reward in a gap junction network inspired by the insect mushroom body.PLoS computational biology · 2024Article
- Article
- A model of working memory for encoding multiple items and ordered sequences exploiting the theta-gamma code.Cognitive neurodynamics · 2023Article
- Emergence of dynamic properties in network hypermotifs.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Computational models of neurotransmission at cerebellar synapses unveil the impact on network computation.Frontiers in computational neuroscience · 2022Review
- Cellular basis of learning and memory in the carotid body.Frontiers in synaptic neuroscience · 2022Review
- Coherence and cognition in the cortex: the fundamental role of parvalbumin, myelin, and the perineuronal net.Brain structure & function · 2021Review
- Regulating synchronous oscillations of cerebellar granule cells by different types of inhibition.PLoS computational biology · 2021Article
- Exacerbation of Epilepsy by Astrocyte Alkalization and Gap Junction Uncoupling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Recent Insights into the Rhythmogenic Core of the Locomotor CPG.International journal of molecular sciences · 2021Review
- Gabaergic Interneurons in Early Brain Development: Conducting and Orchestrated by Cortical Network Activity.Frontiers in molecular neuroscience · 2021Article
- Synaptic Plasticity and Oscillations in Alzheimer's Disease: A Complex Picture of a Multifaceted Disease.Frontiers in molecular neuroscience · 2021Article
- Pannexin-1 Deficiency Decreases Epileptic Activity in Mice.International journal of molecular sciences · 2020Article
- Gap junctions and expression of Cx36, Cx43 and Cx45 in the posterodorsal medial amygdala of adult rats.Histology and histopathology · 2020Article
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3 authors.
Funding
Abstract
Cortical oscillations are thought to be involved in many cognitive functions and processes. Several mechanisms have been proposed to regulate oscillations. One prominent but understudied mechanism is gap junction coupling. Gap junctions are ubiquitous in cortex between GABAergic interneurons. Moreover, recent experiments indicate their strength can be modified in an activity-dependent manner, similar to chemical synapses. We hypothesized that activity-dependent gap junction plasticity acts as a mechanism to regulate oscillations in the cortex. We developed a computational model of gap junction plasticity in a recurrent cortical network based on recent experimental findings. We showed that gap junction plasticity can serve as a homeostatic mechanism for oscillations by maintaining a tight balance between two network states: asynchronous irregular activity and synchronized oscillations. This homeostatic mechanism allows for robust communication between neuronal assemblies through two different mechanisms: transient oscillations and frequency modulation. This implies a direct functional role for gap junction plasticity in information transmission in cortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.