ArticleCritical care medicine2018
Does Regional Lung Strain Correlate With Regional Inflammation in Acute Respiratory Distress Syndrome During Nonprotective Ventilation? An Experimental Porcine Study.
Article in Critical care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04157946 (Risk Assessment of Ventilator-induced Lung Injury in Patients With Acute Respiratory Distress Syndrome), which is not on this map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Risk Assessment of Ventilator-induced Lung Injury in Patients With Acute Respiratory Distress Syndrome: The Role of Morphological Phenotype in ARDS
Who cites it
40 citing papers in PubMed, 61 citations in OpenAlex.
- Protective Ventilation During Controlled and Partial Ventilatory Support in ARDS: Clinical-Physiological Background and Monitoring.Journal of clinical medicine · 2026Review
- Physiology-guided personalized mechanical ventilation to prevent ventilator-induced lung injury.Frontiers in medicine · 2026Review
- Imaging in animal models: bridging experimental findings and human pathophysiology.Critical care (London, England) · 2025Review
- CPAP improves regional lung strain rate and diaphragm velocity of relaxation in experimental self-inflicted lung injury.Critical care (London, England) · 2025Article
- Ventilator-Induced Lung Injury: The Unseen Challenge in Acute Respiratory Distress Syndrome Management.Journal of clinical medicine · 2025Review
- Article
- A machine-learning regional clustering approach to understand ventilator-induced lung injury: a proof-of-concept experimental study.Intensive care medicine experimental · 2024Article
- High Stretch Associated with Mechanical Ventilation Promotes Piezo1-Mediated Migration of Airway Smooth Muscle Cells.International journal of molecular sciences · 2024Article
- Estimation of normal lung weight index in healthy female domestic pigs.Intensive care medicine experimental · 2024Article
- An appraisal of lung computer tomography in very early anti-inflammatory treatment of two different ovine ARDS phenotypes.Scientific reports · 2024Article
- Article
- Dynamic relative regional lung strain estimated by computed tomography and electrical impedance tomography in ARDS patients.Critical care (London, England) · 2023Article
- Dynamic lung aeration and strain with positive end-expiratory pressure individualized to maximal compliance versus ARDSNet low-stretch strategy: a study in a surfactant depletion model of lung injury.Critical care (London, England) · 2023Article
- Polymer Lung Surfactants Attenuate Direct Lung Injury in Mice.ACS biomaterials science & engineering · 2023Article
- Mechanical Ventilation-Related High Stretch Mainly Induces Endoplasmic Reticulum Stress and Thus Mediates Inflammation Response in Cultured Human Primary Airway Smooth Muscle Cells.International journal of molecular sciences · 2023Article
- Endotracheal tube, by the venturi effect, reduces the efficacy of increasing inlet pressure in improving pendelluft.PloS one · 2023Article
- Molecular imaging of inflammation with PET in acute and ventilator-induced lung injury.Frontiers in physiology · 2023Review
- Associating local strains to global pressure-volume mouse lung mechanics using digital image correlation.Physiological reports · 2022Article
- Dynamic relative regional strain visualized by electrical impedance tomography in patients suffering from COVID-19.Journal of clinical monitoring and computing · 2022Observational
- Imaging the acute respiratory distress syndrome: past, present and future.Intensive care medicine · 2022Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIt is known that ventilator-induced lung injury causes increased pulmonary inflammation. It has been suggested that one of the underlying mechanisms may be strain. The aim of this study was to investigate whether lung regional strain correlates with regional inflammation in a porcine model of acute respiratory distress syndrome.
designRetrospective analysis of CT images and positron emission tomography images using [F]fluoro-2-deoxy-D-glucose.
settingUniversity animal research laboratory. SUBJECTS: Seven piglets subjected to experimental acute respiratory distress syndrome and five ventilated controls.
interventionsAcute respiratory distress syndrome was induced by repeated lung lavages, followed by 210 minutes of injurious mechanical ventilation using low positive end-expiratory pressures (mean, 4 cm H2O) and high inspiratory pressures (mean plateau pressure, 45 cm H2O). All animals were subsequently studied with CT scans acquired at end-expiration and end-inspiration, to obtain maps of volumetric strain (inspiratory volume - expiratory volume)/expiratory volume, and dynamic positron emission tomography imaging. Strain maps and positron emission tomography images were divided into 10 isogravitational horizontal regions-of-interest, from which spatial correlation was calculated for each animal. MEASUREMENTS AND MAIN
resultsThe acute respiratory distress syndrome model resulted in a decrease in respiratory system compliance (20.3 ± 3.4 to 14.0 ± 4.9 mL/cm H2O; p < 0.05) and oxygenation (PaO2/FIO2, 489 ± 80 to 92 ± 59; p < 0.05), whereas the control animals did not exhibit changes. In the acute respiratory distress syndrome group, strain maps showed a heterogeneous distribution with a greater concentration in the intermediate gravitational regions, which was similar to the distribution of [F]fluoro-2-deoxy-D-glucose uptake observed in the positron emission tomography images, resulting in a positive spatial correlation between both variables (median R = 0.71 [0.02-0.84]; p < 0.05 in five of seven animals), which was not observed in the control animals.
conclusionIn this porcine acute respiratory distress syndrome model, regional lung strain was spatially correlated with regional inflammation, supporting that strain is a relevant and prominent determinant of ventilator-induced lung injury.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.