Evidence map›Paper›PMID 29528763›Full record

ArticleJournal of geriatric psychiatry and neurology2018

Clinical Markers of Anxiety Subtypes in Parkinson Disease.

Martinus P G Broen, A F G Leentjens, J T Hinkle, A J H Moonen, M L Kuijf, N M Fischer, K Perepezko, A Bakker, G M Pontone

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In one paragraph

Article in Journal of geriatric psychiatry and neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Cognitive Behavioral Therapy for Anxiety in Parkinson's Disease: A Randomized Controlled Trial.Movement disorders : official journal of the Movement Disorder Society · 2021
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  14. The longitudinal associations between cognition, mood and striatal dopaminergic binding in Parkinson's Disease.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2020
    Article
  15. Lewy Body Degenerations as Neuropsychiatric Disorders.The Psychiatric clinics of North America · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Martinus P G Broen1 Department of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands.
A F G Leentjens2 Department of Psychiatry, Maastricht University Medical Center, Maastricht, the Netherlands.
J T Hinkle3 Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
A J H Moonen2 Department of Psychiatry, Maastricht University Medical Center, Maastricht, the Netherlands.
M L Kuijf1 Department of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands.
N M Fischer3 Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
K Perepezko3 Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
A Bakker3 Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
G M Pontone3 Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007309 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI COX, ANDREA L · 1985 to 2019
$43.2M
Anxiety in Parkinson's: Use of quantitative methods to guide rational treatmentK23AG044441 · NIA · JOHNS HOPKINS UNIVERSITY · PI PONTONE, GREGORY MICHAEL · 2014 to 2018
$1.0M
NIA NIH HHS K23 AG044441NIGMS NIH HHS T32 GM007309
6 · The paper itself

Abstract

objectiveThe aim of this work was to investigate marker profiles for proposed anxiety subtypes in Parkinson disease (PD).

methodsWe used the persistent anxiety, episodic anxiety, and avoidance behavior subscales of the Parkinson Anxiety Scale as dependent variables in multivariable linear regression analyses using a cross-sectional data set of 311 patients with PD. Independent variables consisted of a range of demographic, psychiatric, and disease-specific markers.

resultsIn the most parsimonious model of persistent anxiety, higher Hamilton Depression Rating Scale scores, a history of anxiety, fewer years of education, lower Mini-Mental State Examination scores, lower Lawton Instrumental Activities of Daily Living scores, female sex, and complications of therapy (higher Unified Parkinson Disease Rating Scale part IV scores) were all associated with more severe persistent anxiety. Markers associated with more severe episodic anxiety included PD-specific disturbances of activities of daily living, complications of therapy, higher Hamilton Depression Rating Scale scores, female sex, and a history of anxiety. Finally, higher Hamilton Depression Rating Scale scores, a history of anxiety, complications of therapy, and longer disease duration were associated with avoidance behavior. After excluding clinically depressed patients with PD, disease severity and longer disease duration were significantly associated with episodic anxiety, but not with persistent anxiety.

conclusionPersistent anxiety is mainly influenced by nonspecific markers, while episodic anxiety seems to be more PD-specific compared to persistent anxiety and may be more situational or contextual. These results provide support for possible distinct underlying constructs for anxiety subtypes in PD.

Indexed as

Avoidance LearningActivities of Daily LivingAgedAnxietyAnxiety DisordersBiomarkersCross-Sectional StudiesDepressionDepressive DisorderFemaleHumansMaleMiddle AgedParkinson DiseasePsychiatric Status Rating ScalesRisk FactorsBiomarkersanxietydepressionParkinson diseaserisk factor

Identifiers

PMID29528763
PMCPMC5903060

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.