ArticleBiomacromolecules2018
Squaramide-Based Supramolecular Materials for Three-Dimensional Cell Culture of Human Induced Pluripotent Stem Cells and Their Derivatives.
Article in Biomacromolecules, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Phosphine-Functionalized Squaramides as Responsive Organogelators: Structure, Gelation, and Metal-Ion Sensing.The Journal of organic chemistry · 2026Article
- Supramolecular Engineering of Fluid Pressure in Filamentous Hybrid Double Network Hydrogels for 3D Chondrocyte Culture.Advanced healthcare materials · 2026Article
- Covalent Network Formation Rate Controls Depletion-Induced Supramolecular Assembly in Hybrid Double Network Hydrogels.Angewandte Chemie (International ed. in English) · 2026Article
- One- and Two-Dimensional Polymorphism in a Hydrogen-Bonding Bis-Ureido-Squaramide.Angewandte Chemie (International ed. in English) · 2026Article
- Dual-Hydrogen Bond Donor-Functionalized Carbon Nanotube Fibers: Enhancing Anion-Sensing Performance Through Functionalization Approaches.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Modulating self-assembly and polymorph transitions in bisdendronized squaramides.Communications chemistry · 2024Article
- Advancing Synthetic Hydrogels through Nature-Inspired Materials Chemistry.Advanced materials (Deerfield Beach, Fla.) · 2024Review
- Modular mixing of benzene-1,3,5-tricarboxamide supramolecular hydrogelators allows tunable biomimetic hydrogels for control of cell aggregation in 3D.Biomaterials science · 2022Article
- Spatial and Temporal Modulation of Cell Instructive Cues in a Filamentous Supramolecular Biomaterial.ACS applied materials & interfaces · 2022Article
- Squaramide-Based Self-Associating Amphiphiles for Anion Recognition.ChemPlusChem · 2021Article
- Strategies to Improve Nanofibrous Scaffolds for Vascular Tissue Engineering.Nanomaterials (Basel, Switzerland) · 2020Review
- Stab2-Mediated Clearance of Supramolecular Polymer Nanoparticles in Zebrafish Embryos.Biomacromolecules · 2020Article
- Study on Adenovirus Infection in vitro with Nanoself-Assembling Peptide as Scaffolds for 3D Culture.International journal of nanomedicine · 2020Article
- Mimicking Active Biopolymer Networks with a Synthetic Hydrogel.Journal of the American Chemical Society · 2019Article
- Synthesis and supramolecular self-assembly of glutamic acid-based squaramides.Beilstein journal of organic chemistry · 2018Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synthetic hydrogel materials can recapitulate the natural cell microenvironment; however, it is equally necessary that the gels maintain cell viability and phenotype while permitting reisolation without stress, especially for use in the stem cell field. Here, we describe a family of synthetically accessible, squaramide-based tripodal supramolecular monomers consisting of a flexible tris(2-aminoethyl)amine (TREN) core that self-assemble into supramolecular polymers and eventually into self-recovering hydrogels. Spectroscopic measurements revealed that monomer aggregation is mainly driven by a combination of hydrogen bonding and hydrophobicity. The self-recovering hydrogels were used to encapsulate NIH 3T3 fibroblasts as well as human-induced pluripotent stem cells (hiPSCs) and their derivatives in 3D. The materials reported here proved cytocompatible for these cell types with maintenance of hiPSCs in their undifferentiated state essential for their subsequent expansion or differentiation into a given cell type and potential for facile release by dilution due to their supramolecular nature.
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Registered trials
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