ArticleThe Journal of physiology2018
Comparison of the longitudinal effects of persistent periodic breathing and apnoea on cerebral oxygenation in term- and preterm-born infants.
Article in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Apnoea duration and changes in cardiorespiratory and cerebrovascular responses in preterm neonates: a systematic review and meta-analysis.Pediatric research · 2026Pooled it
- Caffeine for Persistent Intermittent Hypoxia in Newborns With and Without Chronic Lung Disease.Pediatric pulmonology · 2025Article
- Long Term Developmental Consequences of Short Apneas and Periodic Breathing in Preterm Infants.Pediatric pulmonology · 2025Article
- Short apneas and periodic breathing in preterm infants in the neonatal intensive care unit-Effects of sleep position, sleep state, and age.Journal of sleep research · 2025Observational
- Apnoea suppresses brain activity in infants.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Developmental consequences of short apneas and periodic breathing in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- The effect of acute respiratory events and respiratory stimulants on EEG-recorded brain activity in neonates: A systematic review.Clinical neurophysiology practice · 2023Review
- The Impact of Preterm Birth on Sleep through Infancy, Childhood and Adolescence and Its Implications.Children (Basel, Switzerland) · 2022Review
- A Review of Cerebral Hemodynamics During Sleep Using Near-Infrared Spectroscopy.Frontiers in neurology · 2020Review
- Challenges and controversies in perinatal physiology.The Journal of physiology · 2018Article
- Assessing ventilatory instability using the response to spontaneous sighs during sleep in preterm infants.Sleep · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
key pointsPeriodic breathing and apnoea were more common in preterm compared to age-matched term-born infants across the first 6 months after term-corrected age. Periodic breathing decreased with age in both term and preterm infants. Apnoea duration was not different between groups; however, the decline in apnoea index with postnatal age observed in the term infants was not seen in the preterm infants. Falls in tissue oxygenation index (brain TOI) associated with apnoeas were greater in the preterm infants at all three ages studied. The clinical significance of falls in brain TOI during periodic breathing and apnoea on neurodevelopmental outcome is unknown and warrants further investigations. ABSTRACT: Periodic breathing and short apnoeas are common in infants, particularly those born preterm, but are thought to be benign. The aim of our study was to assess the incidence and impact of periodic breathing and apnoea on heart rate, oxygen saturation and brain tissue oxygenation index (TOI) in infants born at term and preterm over the first 6 months after term equivalent age. Nineteen term-born infants (38-42 weeks gestational age) and 24 preterm infants (born at 27-36 weeks gestational age) were studied at 2-4 weeks, 2-3 months and 5-6 months post-term-corrected age during sleep. Periodic breathing episodes were defined as three or more sequential apnoeas each lasting ≥3 s and apnoeas as ≥3 s in duration. The mean duration of periodic breathing episodes was longer in term infants than in preterm infants at 2-4 weeks (P < 0.05) and at 5-6 months (P < 0.05); however, the nadir in TOI was significantly less in the term infants at 2-3 months (P < 0.001). Apnoea duration was not different between groups; however, the decline in apnoea index with postnatal age observed in the term infants was not seen in the preterm infants. Falls in TOI associated with apnoeas were greater in the preterm infants at all three ages studied. In conclusion, periodic breathing and short apnoeas were more common in infants born preterm and falls in cerebral oxygenation were greater than in the term group. The clinical significance of this on neurodevelopmental outcome is unknown and warrants further investigations.
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