SynthesisThe journals of gerontology. Series A, Biological sciences and medical sciences2019
Associations Between Aging-Related Changes in Grip Strength and Cognitive Function in Older Adults: A Systematic Review.
Synthesis in The journals of gerontology. Series A, Biological sciences and medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07077460 (Innovative Hand Rehabilitation System With Synchronized Contralateral Haptic Feedback), which is not on this map. Cited by 63 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Innovative Hand Rehabilitation System With Synchronized Contralateral Haptic Feedback
Who cites it
63 citing papers in PubMed, 4 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Prevalence of intrinsic capacity decline among community-dwelling older adults: a systematic review and meta-analysis.Aging clinical and experimental research · 2024Pooled it
- Handgrip strength and risk of cognitive outcomes: new prospective study and meta-analysis of 16 observational cohort studies.GeroScience · 2022Pooled it
- A Coordinated Multi-study Analysis of the Longitudinal Association Between Handgrip Strength and Cognitive Function in Older Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2021Pooled it
- Grip Strength and the Risk of Cognitive Decline and Dementia: A Systematic Review and Meta-Analysis of Longitudinal Cohort Studies.Frontiers in aging neuroscience · 2021Pooled it
- Trial
- Using a Timed Motor Task to Predict One-Year Functional Decline in Amnestic Mild Cognitive Impairment.Journal of Alzheimer's disease : JAD · 2020Trial
- Neural contributions to age-related handgrip weakness revealed by multi-finger force deficit and dual-task testing.GeroScience · 2026Article
- Physical function domain associations with cognitive domains in community-dwelling older adults.medRxiv : the preprint server for health sciences · 2026Article
- The crossroads between osteosarcopenia and intrinsic capacity-a narrative review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Review
- Trajectories of frailty, grip strength and gait speed preceding dementia: a nested case-control study.Age and ageing · 2026Article
- Physical fitness and cognitive function: a cross-sectional study among adults in Qatar.BMJ open · 2026Article
- Associations between independent or concurrent decline in upper and lower limb strength and cognitive impairment.BMC geriatrics · 2026Article
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- Article
- Beyond grip strength: selective slowing of grip force release but not initiation dynamics in a go/no-go target force-matching task.Frontiers in aging neuroscience · 2026Article
- Dose-Response Associations of Grip Strength and Gait Speed With Multidimensional Mental Health.Aging medicine (Milton (N.S.W)) · 2025Article
- Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.Nature communications · 2025Article
- Article
- Article
- Association between sarcopenic obesity and dementia in the Chinese elderly using different definitions of obesity: evidence from the CHARLS.Frontiers in aging neuroscience · 2025Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 5 institutions in 3 countries.
Funding
Abstract
objectivesGrip strength and cognitive function reflect upper body muscle strength and mental capacities. Cross-sectional research has suggested that in old age these two processes are moderately to highly associated, and that an underlying common cause drives this association. Our aim was to synthesize and evaluate longitudinal research addressing whether changes in grip strength are associated with changes in cognitive function in healthy older adults.
methodsWe systematically reviewed English-language research investigating the longitudinal association between repeated measures of grip strength and of cognitive function in community-dwelling older adults to evaluate the extent to which the two indices decline concurrently. We used four search engines: Embase, PsychINFO, PubMed, and Web of Science.
resultsOf 459 unique citations, 6 met our full criteria: 4 studies reported a longitudinal association between rates of change in grip strength and cognitive function in older adults, 2 of which reported the magnitudes of these associations as ranging from low to moderate; 2 studies reported significant cross-sectional but not longitudinal associations among rates of change. All studies concluded that cognitive function and grip strength declined, on average, with increasing age, although with little to no evidence for longitudinal associations among rates of change.
conclusionsFuture research is urged to expand the study of physical and cognitive associations in old age using a within-person and multi-study integrative approach to evaluate the reliability of longitudinal results with greater emphasis on the magnitude of this association. SYSTEMATIC REVIEW REGISTRATION NUMBER: CRD42016038544.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.