ArticleAmerican journal of hypertension2018
West African Ancestry and Nocturnal Blood Pressure in African Americans: The Jackson Heart Study.
Article in American journal of hypertension, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 7 citations in OpenAlex.
- The Prevalence and Correlates of Arterial Stiffness in Patients With Treated Hypertension: Oscillometric Pulse Wave Analysis During 24-h Ambulatory Blood Pressure Monitoring.International journal of hypertension · 2026Article
- Relative impact of genetic ancestry and neighborhood socioeconomic status on all-cause mortality in self-identified African Americans.PloS one · 2022Article
- Nocturnal Dipping and Left Ventricular Mass Index in the Chronic Kidney Disease in Children Cohort.Clinical journal of the American Society of Nephrology : CJASN · 2022Article
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14 authors at 6 institutions in 1 country.
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Abstract
backgroundAfrican Americans have a higher prevalence of nocturnal hypertension and nondipping blood pressure than European Americans, but the genetic contribution to these racial differences remains unclear. We assessed the association of the percentage West African genetic ancestry with nocturnal hypertension and nondipping blood pressure in 932 African Americans from the Jackson Heart Study.
methodsUsing percentage West African ancestry determined from 389 ancestry informative markers, participants were categorized into tertiles (tertile 1 [low]: <79.3%, tertile 2: ≥79.3-86.3%, and tertile 3 [high]: >86.3%). Nocturnal hypertension was defined as mean nighttime (midnight-6 am) systolic (SBP)/diastolic blood pressure ≥120/70 mm Hg. Nondipping blood pressure was defined as mean nighttime-to-daytime (10 am-8 pm) SBP ratio >0.90.
resultsNocturnal hypertension was present in 57.9% of participants; 66.6% had nondipping blood pressure. The mean age was 59.4 years, 32.8% were male, and 56.0% were taking antihypertensive medication. The prevalence ratios (95% confidence interval) adjusted for age, sex, cardiovascular disease risk factors, and socioeconomic and psychosocial factors comparing participants with moderate and high to those with low percentage West African ancestry for nocturnal hypertension were 0.98 (0.87-1.10) and 0.95 (0.84-1.08), respectively, and for nondipping blood pressure was 0.96 (0.86-1.07) and 0.98 (0.88-1.09), respectively.
conclusionsWest African ancestry was not associated with nocturnal hypertension and nondipping blood pressure among African Americans. While rare genetic variants cannot be ruled out, these data highlight the need to better understand how environmental and behavioral factors contribute to differences in nocturnal blood pressure among African Americans compared with European Americans.
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