Evidence map›Paper›PMID 29528265›Full record

ArticlePathogens and global health2018

Current progress of immunoinformatics approach harnessed for cellular- and antibody-dependent vaccine design.

Ada Kazi, Candy Chuah, Abu Bakar Abdul Majeed, Chiuan Herng Leow, Boon Huat Lim, Chiuan Yee Leow

Erratum issuedAbstract read
In one paragraph

Article in Pathogens and global health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 66 papers.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed.

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  19. Completing the pieces of a puzzle: in-depth probing ofClinical and experimental vaccine research · 2024
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Ada Kazia Institute for Research in Molecular Medicine (INFORMM) , Universiti Sains Malaysia , Kelantan , Malaysia.ORCID 0000-0002-7673-6650
Candy Chuahc School of Medical Sciences , Universiti Sains Malaysia , Kelantan , Malaysia.ORCID 0000-0001-6113-5070
Abu Bakar Abdul Majeede Faculty of Pharmacy , Universiti Teknologi MARA , Selangor , Malaysia.
Chiuan Herng Leowd Institute for Research in Molecular Medicine (INFORMM) , Universiti Sains Malaysia , Penang , Malaysia.ORCID 0000-0003-0849-428X
Boon Huat Limb School of Health Sciences , Universiti Sains Malaysia , Kelantan , Malaysia.ORCID 0000-0003-3838-1526
Chiuan Yee Leowa Institute for Research in Molecular Medicine (INFORMM) , Universiti Sains Malaysia , Kelantan , Malaysia.ORCID 0000-0002-6919-5921

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunoinformatics plays a pivotal role in vaccine design, immunodiagnostic development, and antibody production. In the past, antibody design and vaccine development depended exclusively on immunological experiments which are relatively expensive and time-consuming. However, recent advances in the field of immunological bioinformatics have provided feasible tools which can be used to lessen the time and cost required for vaccine and antibody development. This approach allows the selection of immunogenic regions from the pathogen genomes. The ideal regions could be developed as potential vaccine candidates to trigger protective immune responses in the hosts. At present, epitope-based vaccines are attractive concepts which have been successfully trailed to develop vaccines which target rapidly mutating pathogens. In this article, we provide an overview of the current progress of immunoinformatics and their applications in the vaccine design, immune system modeling and therapeutics.

Indexed as

Immunity, CellularImmunity, HumoralAnimalsComputational BiologyDrug DiscoveryEpitopesHumansVaccinesEpitopesVaccinesAntigenbioinformaticsepitope predictionhuman leukocyte antigen (HLA)immunoinformaticsin silico toolsmajor histocompability (MHC)reverse vaccinologyvaccine design

Identifiers

PMID29528265
PMCPMC6056828

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.