ArticlePediatric pulmonology2018
Divergent transcriptional profiles in pediatric asthma patients of low and high socioeconomic status.
Article in Pediatric pulmonology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Atopic Dermatitis Across Shades of Skin.American journal of clinical dermatology · 2023Review
- Structural Racism and the Social Determinants of Health in Asthma.Advances in experimental medicine and biology · 2023Article
- School Nurse Perspectives on School-Supervised Asthma Therapy: A Qualitative Study.Pediatric allergy, immunology, and pulmonology · 2022Article
- Socio-demographic characteristics of children and young adults with varied asthma control- does it make a difference?Malawi medical journal : the journal of Medical Association of Malawi · 2022Article
- Transcriptomic signatures of psychomotor slowing in peripheral blood of depressed patients: evidence for immunometabolic reprogramming.Molecular psychiatry · 2021Article
- Early-Life Adversity Leaves Its Imprint on the Oral Microbiome for More Than 20 Years and Is Associated with Long-Term Immune Changes.International journal of molecular sciences · 2021Article
- Structural racism and its pathways to asthma and atopic dermatitis.The Journal of allergy and clinical immunology · 2021Review
- Protein and gene markers of metabolic dysfunction and inflammation together associate with functional connectivity in reward and motor circuits in depression.Brain, behavior, and immunity · 2020Article
- The COVID-19 Pandemic: Does Our Early Life Environment, Life Trajectory and Socioeconomic Status Determine Disease Susceptibility and Severity?International journal of molecular sciences · 2020Review
- Twin Research in the Post-Genomic Era: Dissecting the Pathophysiological Effects of Adversity and the Social Environment.International journal of molecular sciences · 2020Review
- Structural and Social Determinants of Health in Asthma in Developed Economies: a Scoping Review of Literature Published Between 2014 and 2019.Current allergy and asthma reports · 2020Article
- Health Disparities in COVID-19: Addressing the Role of Social Determinants of Health in Immune System Dysfunction to Turn the Tide.Frontiers in public health · 2020Article
- Asthma.Pediatrics in review · 2019Review
- Epigenetic and Neurological Impairments Associated with Early Life Exposure to Persistent Organic Pollutants.International journal of genomics · 2019Review
- Genomic Predictors of Asthma Phenotypes and Treatment Response.Frontiers in pediatrics · 2019Review
- Socioeconomic Status Affects Postoperative Time to Union in Pediatric Patients with a Surgically Treated Fracture.JB & JS open accessArticle
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8 authors at 3 institutions in 1 country.
Funding
Abstract
aimThere are marked socioeconomic disparities in pediatric asthma control, but the molecular origins of these disparities are not well understood. To fill this gap, we performed genome-wide expression profiling of monocytes and T-helper cells from pediatric asthma patients of lower and higher socioeconomic status (SES).
methodNinety-nine children with asthma participated in a cross-sectional assessment. Out of which 87% were atopic, and most had disease of mild (54%) or moderate (29%) severity. Children were from lower-SES (n = 49; household income <$50 000) or higher-SES (n = 50; household income >$140 000) families. Peripheral blood monocytes and T-helper cells were isolated for genome-wide expression profiling of mRNA.
resultsLower-SES children had worse asthma quality of life relative to higher-SES children, by both their own and their parents' reports. Although the groups had similar disease severity and potential confounds were controlled, their transcriptional profiles differed notably. The monocytes of lower-SES children showed transcriptional indications of up-regulated anti-microbial and pro-inflammatory activity. The T-helper cells of lower-SES children also had comparatively reduced expression of genes encoding γ-interferon and tumor necrosis factor-α, cytokines that orchestrate Type 1 responses. They also showed up-regulated activity of transcription factors that polarize cells towards Type 2 responses and promote Th17 cell maturation.
conclusionCollectively, these patterns implicate pro-inflammatory monocytes and Type 2 cytokine activity as mechanisms contributing to worse asthma control among lower-SES children.
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