ArticleHuman brain mapping2018
Vestibular brain changes within 70 days of head down bed rest.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- The human brain in space: a meta-analysis of neuroimaging evidence.Frontiers in psychology · 2026Pooled it
- Exercise effects on bed rest-induced brain changes.PloS one · 2018Trial
- The impact of 14-day head-down bed rest with or without an exercise countermeasure on standing balance control: a randomized controlled trial.NPJ microgravity · 2026Article
- Neuromotor changes in postural control following bed rest.The Journal of physiology · 2026Review
- Effects of seasonal factors on brain function: Systematic review and future perspectives.iScience · 2025Article
- Reduced postural stability in men and women aged 55-65 following 14 days of head-down bed rest.Scientific reports · 2025Article
- Thirty minutes of daily artificial gravity does not mitigate head down tilt induced brain activity changes during cognitive task performance.Frontiers in neurology · 2025Article
- Altered gravity and time perception: a brief review.Frontiers in psychology · 2025Review
- taVNS as a potential countermeasure for neurocognitive decline in microgravity.Frontiers in neuroscience · 2025Article
- Daily artificial gravity partially mitigates vestibular processing changes associated with head-down tilt bedrest.NPJ microgravity · 2024Article
- Effects of intermittent seating upright, lower body negative pressure, and exercise on functional tasks performance after head-down tilt bed rest.Frontiers in physiology · 2024Article
- Daily artificial gravity is associated with greater neural efficiency during sensorimotor adaptation.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Cognition in zero gravity: Effects of non-terrestrial gravity on human behaviour.Quarterly journal of experimental psychology (2006) · 2023Article
- Changes in working memory brain activity and task-based connectivity after long-duration spaceflight.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Impact of different ground-based microgravity models on human sensorimotor system.Frontiers in physiology · 2023Review
- Cerebrocortical activation following unilateral labyrinthectomy in mice characterized by whole-brain clearing: implications for sensory reweighting.Scientific reports · 2022Article
- Monitoring the Impact of Spaceflight on the Human Brain.Life (Basel, Switzerland) · 2022Review
- Modulation of biological motion perception in humans by gravity.Nature communications · 2022Article
- Brain and Behavioral Evidence for Reweighting of Vestibular Inputs with Long-Duration Spaceflight.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Future research directions to identify risks and mitigation strategies for neurostructural, ocular, and behavioral changes induced by human spaceflight: A NASA-ESA expert group consensus report.Frontiers in neural circuits · 2022Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
Head-down-tilt bed rest (HDBR) is frequently utilized as a spaceflight analog research environment to study the effects of axial body unloading and fluid shifts that are associated with spaceflight in the absence of gravitational modifications. HDBR has been shown to result in balance changes, presumably due to sensory reweighting and adaptation processes. Here, we examined whether HDBR results in changes in the neural correlates of vestibular processing. Thirteen men participated in a 70-day HDBR intervention; we measured balance, functional mobility, and functional brain activity in response to vestibular stimulation at 7 time points before, during, and after HDBR. Vestibular stimulation was administered by means of skull taps, resulting in activation of the vestibular cortex and deactivation of the cerebellar, motor, and somatosensory cortices. Activation in the bilateral insular cortex, part of the vestibular network, gradually increased across the course of HDBR, suggesting an upregulation of vestibular inputs in response to the reduced somatosensory inputs experienced during bed rest. Furthermore, greater increase of activation in multiple frontal, parietal, and occipital regions in response to vestibular stimulation during HDBR was associated with greater decrements in balance and mobility from before to after HDBR, suggesting reduced neural efficiency. These findings shed light on neuroplastic changes occurring with conditions of altered sensory inputs, and reveal the potential for central vestibular-somatosensory convergence and reweighting with bed rest.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.