ArticleHuman brain mapping2018
Heritability of aggression following social evaluation in middle childhood: An fMRI study.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Genetics of child aggression, a systematic review.Translational psychiatry · 2024Pooled it
- The causal role of the bilateral ventrolateral prefrontal cortices on emotion regulation of social feedback.Human brain mapping · 2022Trial
- Being praised and criticized in adolescents and adults: Age-related changes in neural responses to social evaluations.Developmental cognitive neuroscience · 2026Article
- In the moment, out of reach? Experience sampling with adolescents in the context of school smartphone bans and shifting societal norms.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2026Article
- Prefrontal-Dependent and Gender-Specific Modulation of Guilt Emotion on Human Early Visual Perception.Behavioral sciences (Basel, Switzerland) · 2025Article
- Genetic and environmental influences on structural brain development from childhood to adolescence: A longitudinal twin study on cortical thickness, surface area, and subcortical volume.Developmental cognitive neuroscience · 2024Article
- Behavioral and neural responses to social rejection: Individual differences in developmental trajectories across childhood and adolescence.Developmental cognitive neuroscience · 2024Article
- Development of social feedback processing and responses in childhood: an fMRI test-replication design in two age cohorts.Social cognitive and affective neuroscience · 2023Article
- Temporal discounting for self and friends in adolescence: A fMRI study.Developmental cognitive neuroscience · 2023Article
- Your smile won't affect me: Association between childhood maternal antipathy and adult neural reward function in a transdiagnostic sample.Translational psychiatry · 2023Article
- Thumbs up or thumbs down: neural processing of social feedback and links to social motivation in adolescent girls.Social cognitive and affective neuroscience · 2023Article
- A neurocognitive model of early onset persistent and desistant antisocial behavior in early adulthood.Frontiers in human neuroscience · 2023Review
- Structural and functional biomarkers of the insula subregions predict sex differences in aggression subscales.Human brain mapping · 2022Article
- Associations between social behaviors and experiences with neural correlates of implicit emotion regulation in middle childhood.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Neurobiological correlates of the social and emotional impact of peer victimization: A review.Frontiers in psychiatry · 2022Review
- The nature of the self: Neural analyses and heritability estimates of self-evaluations in middle childhood.Human brain mapping · 2021Article
- Social experience calibrates neural sensitivity to social feedback during adolescence: A functional connectivity approach.Developmental cognitive neuroscience · 2021Article
- Neural and behavioral signatures of social evaluation and adaptation in childhood and adolescence: The Leiden consortium on individual development (L-CID).Developmental cognitive neuroscience · 2020Review
- Heightened neural sensitivity to social exclusion in boys with a history of low peer preference during primary school.Developmental cognitive neuroscience · 2020Article
- Genetic and environmental influences on structure of the social brain in childhood.Developmental cognitive neuroscience · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Middle childhood marks an important phase for developing and maintaining social relations. At the same time, this phase is marked by a gap in our knowledge of the genetic and environmental influences on brain responses to social feedback and their relation to behavioral aggression. In a large developmental twin sample (509 7- to 9-year-olds), the heritability and neural underpinnings of behavioral aggression following social evaluation were investigated, using the Social Network Aggression Task (SNAT). Participants viewed pictures of peers that gave positive, neutral, or negative feedback to the participant's profile. Next, participants could blast a loud noise toward the peer as an index of aggression. Genetic modeling revealed that aggression following negative feedback was influenced by both genetics and environmental (shared as well as unique environment). On a neural level (n = 385), the anterior insula and anterior cingulate cortex gyrus (ACCg) responded to both positive and negative feedback, suggesting they signal for social salience cues. The medial prefrontal cortex (mPFC) and inferior frontal gyrus (IFG) were specifically activated during negative feedback, whereas positive feedback resulted in increased activation in caudate, supplementary motor cortex (SMA), and dorsolateral prefrontal cortex (DLPFC). Decreased SMA and DLPFC activation during negative feedback was associated with more aggressive behavior after negative feedback. Moreover, genetic modeling showed that 13%-14% of the variance in dorsolateral PFC activity was explained by genetics. Our results suggest that the processing of social feedback is partly explained by genetic factors, whereas shared environmental influences play a role in behavioral aggression following feedback.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.