ArticleHuman brain mapping2018
Presurgical language fMRI: Clinical practices and patient outcomes in epilepsy surgical planning.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Role of Functional Imaging Techniques to Assess Motor and Language Cortical Plasticity in Glioma Patients: A Systematic Review.Neural plasticity · 2019Pooled it
- A systematic review of the impact of stimulus presentation modality on fMRI studies for presurgical mapping.Neuroimage. Reports · 2026Review
- A language network in the individualized functional connectomes of 1199 human brains doing arbitrary tasks.Nature communications · 2026Article
- Challenges and opportunities for advancing functional MRI in clinical practice.Brain : a journal of neurology · 2025Article
- Functional Connectivity Relationships to Longitudinal Motor Outcomes Differ in Very Preterm Children With and Without Brain Injury.Neurology. Clinical practice · 2025Article
- Evolutionary Strategies Enable Systematic and Reliable Uncertainty Quantification: A Proof-of-Concept Pilot Study on Resting-State Functional MRI Language Lateralization.Journal of imaging informatics in medicine · 2025Article
- Consensus recommendations for clinical functional MRI applied to language mapping.Aperture neuro · 2025Article
- Predicting memory decline from left temporal lobe epilepsy surgery using preoperative fMRI: a multicenter study.NeuroImage. Clinical · 2025Observational
- Mapping Cognition in Epilepsy: From the Lab to the Clinic.Epilepsy currents · 2024Review
- Chinese Verbal Fluency Deficiency in Temporal Lobe Epilepsy with and without Hippocampal Sclerosis: A Multiscale Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The Commonality and Individuality of Human Brains When Performing Tasks.Brain sciences · 2024Article
- Methods for and Use of Functional Magnetic Resonance Imaging in Psychiatry.Advances in neurobiology · 2024Review
- Functional MR elastography measures visual cortex stiffening proportional to visual contrast intensity in regions of activation.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Test-retest reliability of the "Home Town Walk" fMRI paradigm for memory activation and lateralization in the pre-surgical evaluation of patients with temporal lobe epilepsy.Frontiers in neurology · 2024Article
- Bilateral and asymmetrical localization of language function identified by the superselective infusion of propofol in an epilepsy patient with a mild malformation of cortical development: illustrative case.Journal of neurosurgery. Case lessons · 2023Article
- Standardization of presurgical language fMRI in Greek population: Mapping of six critical regions.Brain and behavior · 2022Article
- Overt speech critically changes lateralization index and did not allow determination of hemispheric dominance for language: an fMRI study.BMC neuroscience · 2021Article
- Clinical Utility of Transcranial Magnetic Stimulation (TMS) in the Presurgical Evaluation of Motor, Speech, and Language Functions in Young Children With Refractory Epilepsy or Brain Tumor: Preliminary Evidence.Frontiers in neurology · 2021Article
- A Data-Based Approach for Selecting Pre- and Intra-Operative Language Mapping Tasks.Frontiers in neuroscience · 2021Article
- Divergence between functional magnetic resonance imaging and clinical indicators of language dominance in preoperative language mapping.Human brain mapping · 2020Article
Corrections and comments
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Authors and funding
15 authors at 8 institutions in 4 countries.
Funding
Abstract
The goal of this study was to document current clinical practice and report patient outcomes in presurgical language functional MRI (fMRI) for epilepsy surgery. Epilepsy surgical programs worldwide were surveyed as to the utility, implementation, and efficacy of language fMRI in the clinic; 82 programs responded. Respondents were predominantly US (61%) academic programs (85%), and evaluated adults (44%), adults and children (40%), or children only (16%). Nearly all (96%) reported using language fMRI. Surprisingly, fMRI is used to guide surgical margins (44% of programs) as well as lateralize language (100%). Sites using fMRI for localization most often use a distance margin around activation of 10mm. While considered useful, 56% of programs reported at least one instance of disagreement with other measures. Direct brain stimulation typically confirmed fMRI findings (74%) when guiding margins, but instances of unpredicted decline were reported by 17% of programs and 54% reported unexpected preservation of function. Programs reporting unexpected decline did not clearly differ from those which did not. Clinicians using fMRI to guide surgical margins do not typically map known language-critical areas beyond Broca's and Wernicke's. This initial data shows many clinical teams are confident using fMRI not only for language lateralization but also to guide surgical margins. Reported cases of unexpected language preservation when fMRI activation is resected, and cases of language decline when it is not, emphasize a critical need for further validation. Comprehensive studies comparing commonly-used fMRI paradigms to predict stimulation mapping and post-surgical language decline remain of high importance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.