ArticleHuman brain mapping2018
Impaired rich club and increased local connectivity in children with traumatic brain injury: Local support for the rich?
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Challenges and opportunities for neuroimaging in young patients with traumatic brain injury: a coordinated effort towards advancing discovery from the ENIGMA pediatric moderate/severe TBI group.Brain imaging and behavior · 2021Pooled it
- The structural connectome in traumatic brain injury: A meta-analysis of graph metrics.Neuroscience and biobehavioral reviews · 2019Pooled it
- The second decade of DTI in TBI Part 2: a systematic review of moderate and severe TBI.Frontiers in neurologyPooled it
- Altered structural networks and cognitive functioning in long-term survivors of pediatric brain tumors.Neuroimage. Reports · 2026Article
- Cortical Morphometric Similarity Remodeling in Traumatic Brain Injury Links Cognitive Impairments with Transcriptional Changes and Type-Specific Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Alterations in topology, cost, and dynamics of gamma-band EEG functional networks in a preclinical model of traumatic brain injury.Network neuroscience (Cambridge, Mass.) · 2025Article
- Brain network fingerprints of Alzheimer's disease risk factors in mouse models with humanized APOE alleles.Magnetic resonance imaging · 2024Article
- Effects of second language acquisition on brain functional networks at different developmental stages.Brain imaging and behavior · 2024Article
- APOE, Immune Factors, Sex, and Diet Interact to Shape Brain Networks in Mouse Models of Aging.bioRxiv : the preprint server for biology · 2024Article
- Graph Analysis of the Visual Cortical Network during Naturalistic Movie Viewing Reveals Increased Integration and Decreased Segregation Following Mild TBI.Vision (Basel, Switzerland) · 2024Article
- Exploring personalized structural connectomics for moderate to severe traumatic brain injury.Network neuroscience (Cambridge, Mass.) · 2023Article
- Normalization effect of levodopa on hierarchical brain function in Parkinson's disease.Network neuroscience (Cambridge, Mass.) · 2022Article
- Early Changes in the White Matter Microstructure and Connectome Underlie Cognitive Deficit and Depression Symptoms After Mild Traumatic Brain Injury.Frontiers in neurology · 2022Article
- Topological Aberrance of Structural Brain Network Provides Quantitative Substrates of Post-Traumatic Brain Injury Attention Deficits in Children.Brain connectivity · 2021Article
- Disrupted topological properties of functional networks in epileptic children with generalized tonic-clonic seizures.Brain and behavior · 2020Article
- Link-usage asymmetry and collective patterns emerging from rich-club organization of complex networks.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Impaired brain network architecture in Cushing's disease based on graph theoretical analysis.Aging · 2020Article
- Network diffusion modeling predicts neurodegeneration in traumatic brain injury.Annals of clinical and translational neurology · 2020Article
- Predicting Concussion Outcome by Integrating Finite Element Modeling and Network Analysis.Frontiers in bioengineering and biotechnology · 2020Article
- Rich-club in the brain's macrostructure: Insights from graph theoretical analysis.Computational and structural biotechnology journal · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent evidence has shown the presence of a "rich club" in the brain, which constitutes a core network of highly interconnected and spatially distributed brain regions, important for high-order cognitive processes. This study aimed to map the rich club organization in 17 young patients with moderate to severe TBI (15.71 ± 1.75 years) in the chronic stage of recovery and 17 age- and gender-matched controls. Probabilistic tractography was performed on diffusion weighted imaging data to construct the edges of the structural connectomes using number of streamlines as edge weight. In addition, the whole-brain network was divided into a rich club network, a local network and a feeder network connecting the latter two. Functional outcome was measured with a parent questionnaire for executive functioning. Our results revealed a significantly decreased rich club organization (p values < .05) and impaired executive functioning (p < .001) in young patients with TBI compared with controls. Specifically, we observed reduced density values in all three subnetworks (p values < .005) and a reduced mean strength in the rich club network (p = .013) together with an increased mean strength in the local network (p = .002) in patients with TBI. This study provides new insights into the nature of TBI-induced brain network alterations and supports the hypothesis that the local subnetwork tries to compensate for the biologically costly subnetwork of rich club nodes after TBI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.