Evidence map›Paper›PMID 29528043›Full record

ArticleEuropean endodontic journal2017

Methylene Blue and Hydrogen Peroxide for Photodynamic Inactivation in Root Canal - A New Protocol for Use in Endodontics.

Aguinaldo S Garcez, Michael R Hamblin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European endodontic journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  5. Article
  6. Article
  7. Microorganisms · 2023
    Review
  8. Review
  9. Membrane damage as mechanism of photodynamic inactivation using Methylene blue and TMPyP in Escherichia coli and Staphylococcus aureus.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2022
    Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Aguinaldo S GarcezDepartment of Oral Microbiology (A.S.G.), São Leopoldo Mandic Institute and Dental School, Campinas SP, Brazil; Department of Phototherapy (M.R.H.), Wellman Center for Photomedicine, Massachusetts General Hospital, Boston MA, USA; Department of Dermatology (M.R.H.), Harvard Medical School, Boston MA, USA; Department of Health Science and Technology (M.R.H.) Harvard-MIT, Cambridge, MA, USA.
Michael R HamblinDepartment of Oral Microbiology (A.S.G.), São Leopoldo Mandic Institute and Dental School, Campinas SP, Brazil; Department of Phototherapy (M.R.H.), Wellman Center for Photomedicine, Massachusetts General Hospital, Boston MA, USA; Department of Dermatology (M.R.H.), Harvard Medical School, Boston MA, USA; Department of Health Science and Technology (M.R.H.) Harvard-MIT, Cambridge, MA, USA.
Harvard University · USMassachusetts General Hospital · US

Funding

Photodynamic Therapy of Localized InfectionsR01AI050875 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2003 to 2017
$4.8M
Synergistic Photodynamic Therapy for Catherer-Associated Urinary Tract InfectionsR21AI121700 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2016 to 2017
$462k
NIAID NIH HHS R01 AI050875NIAID NIH HHS R21 AI121700
6 · The paper itself

Abstract

objectiveAntimicrobial photodynamic therapy (aPDT) is a controversial approach for endodontic disinfection. The objective of this study was to test the photosensitiser (PS) concentration and assess the optical shielding phenomenon, the use of hydrogen peroxide (H

methodsDifferent parameters for aPDT were tested. Aqueous solutions of methylene blue (MB) at 50, 100, 150 and 300 μM were tested

resultsROS production was inversely proportional to the MB concentration in the solution due to quenching of MB. Optical shielding limited light penetration at high MB concentrations. The use of H

conclusionPS concentration of about 50 μM, biofilm pre-treatment with H

Indexed as

Antimicrobial photodynamic therapydisinfectionhydrogen peroxidelasersmethylene blue

Identifiers

PMID29528043
PMCPMC5844508
OpenAlexW2769106195

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.