Trial reportInternational wound journal2018
Closed-incision negative pressure therapy to reduce groin wound infections in vascular surgery: a randomised controlled trial.
Trial report in International wound journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 8 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Prevention of infection in aortic or aortoiliac peripheral arterial reconstruction.The Cochrane database of systematic reviews · 2025Pooled it
- The wound adjuncts effect of closed incision negative pressure wound therapy on stopping groin surgical site wound infection in arterial surgery: A meta-analysis.International wound journal · 2023Pooled it
- Effect of prophylactic negative pressure treatment for post-surgery groin wounds management in vascular surgery: A meta-analysis.International wound journal · 2023Pooled it
- Negative pressure wound therapy for surgical wounds healing by primary closure.The Cochrane database of systematic reviews · 2022Pooled it
- Negative pressure wound therapy for surgical wounds healing by primary closure.The Cochrane database of systematic reviews · 2020Pooled it
- Pooled it
- Negative pressure wound therapy for surgical wounds healing by primary closure.The Cochrane database of systematic reviews · 2020Pooled it
- Negative pressure wound therapy for surgical wounds healing by primary closure.The Cochrane database of systematic reviews · 2019Pooled it
- Final results of the PräVAC trial: prevention of wound complications following inguinal lymph node dissection in patients with penile cancer using epidermal vacuum-assisted wound closure.World journal of urology · 2021Trial
- Artificial Intelligence Versus Human Systematic Literature Review Into Negative-pressure Wound Therapy in Plastic Surgery.Plastic and reconstructive surgery. Global open · 2025Article
- Outcomes of Reconstructive Surgery Using Vacuum-Assisted Closure in Patients With Complex Wounds.Cureus · 2024Article
- Comparison of negative pressure wound therapy against normal dressing after vascular surgeries for inguinal wounds: A systematic review and meta-analysis.Surgery open science · 2024Article
- RETRACTED: Effects of negative-pressure wound therapy in the prevention of surgical-site wound infection after vascular surgery: A meta-analysis.International wound journal · 2024Article
- Review
- Incisional negative pressure wound therapy for the prevention of surgical site infection: an up-to-date meta-analysis and trial sequential analysis.EClinicalMedicine · 2023Article
- Article
- Closed Incision Negative Pressure Therapy versus Standard of Care in Reduction of Surgical Site Complications: A Systematic Review and Meta-analysis.Plastic and reconstructive surgery. Global open · 2023Article
- Effects of vacuum sealing drainage to improve the therapeutic effect in patients with orthopedic trauma and to reduce post-operative infection and lower-limb deep venous thrombosis.Experimental and therapeutic medicine · 2020Article
- Review
- Meta-analysis Comparing Outcomes of Two Different Negative Pressure Therapy Systems in Closed Incision Management.Plastic and reconstructive surgery. Global open · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Groin wound infections pose a major problem in vascular surgery. Closed-incision negative pressure therapy (ciNPT) was especially designed for the management of incisions at risk of surgical site infections. The aim of this study was to investigate whether ciNPT is able to reduce the incidence of wound infections after vascular surgery. Data on 132 consecutive patients, scheduled for vascular surgery with a longitudinal femoral cutdown, were collected prospectively. All patients were randomised either to the ciNPT group (n = 64) or the control group (n = 68) with conventional dressing. In the ciNPT group, the foam dressing was applied intraoperatively and removed after 5 days. The control group received an absorbent dressing. All wounds were evaluated after 5 and 42 days. Infections were graded according the Szilagyi classification (I-III°). There were no significant differences between both groups considering patient characteristics. Indications for surgery were peripheral arterial disease in 95% (125/132) and aneurysm in 5% (7/132). The overall infection rates were 14% (9/64) in the ciNPT group and 28% (19/68) in the control group (P = 0·055). Early infections were observed in 6% (4/64) of the ciNPT group and 15% (10/68) of the control group (P = 0·125). ciNPT did not reduce infection rates associated with different risk factors for infection. While the experiences with the ciNPT device were encouraging, the study fails to provide evidence of the efficacy of the device to reduce groin wound infections after vascular surgery. It illustrates far more that larger multicentre studies are required and appear promising to provide further evidence for the use of ciNPT.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.