ReviewCurrent psychiatry reports2018
Possible Pharmacodynamic and Pharmacokinetic Drug-Drug Interactions That Are Likely to Be Clinically Relevant and/or Frequent in Bipolar Disorder.
Review in Current psychiatry reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Bipolar Disorder in Older Adults: A Comprehensive Overview of Pharmacotherapy Patterns and Clinical Considerations.Drugs & aging · 2026Review
- Trajectories of psychotropic drug use patterns in psychiatric inpatients with acute depressive episodes of bipolar disorder: results from a pharmacovigilance program in German-speaking countries from 2007 to 2024.International journal of bipolar disorders · 2026Article
- The Effect of Oxcarbazepine on the Pharmacokinetics of Single-Dose Aripiprazole in a Rat Model.Medicines (Basel, Switzerland) · 2026Article
- Knowledge, attitudes, practices, and barriers toward drug-drug interaction management among pharmacists in Riyadh, Saudi Arabia: a cross-sectional study.Frontiers in public health · 2026Article
- Lithium intoxication complicated by severe bradycardia after single-incision laparoscopic sleeve gastrectomy: a case report and literature review.Frontiers in surgery · 2025Article
- Screening indicators to evaluate the clinical significance of drug-drug interactions in polypharmacy among older adults with psychiatric disorders: a delphi study.BMC psychiatry · 2024Article
- Pharmacokinetics and Pharmacodynamics: A Comprehensive Analysis of the Absorption, Distribution, Metabolism, and Excretion of Psychiatric Drugs.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Hemodynamics and arrhythmia disorder caused by lithium poisoning: A case report.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Article
- Prevalence and clinical significance of potential drug-drug interactions among lung transplant patients.Frontiers in pharmacology · 2024Article
- Treatment of bipolar depression: clinical practice vs. adherence to guidelines-data from a Bavarian drug surveillance project.Frontiers in psychiatry · 2024Article
- Assessment of community pharmacists' knowledge about drug-drug interactions in Jeddah, Saudi Arabia.Frontiers in pharmacology · 2023Article
- Sinus bradycardia with haemodynamic compromise following lithium intoxication.BMJ case reports · 2021Article
- Atypical Antipsychotics and Metabolic Syndrome: From Molecular Mechanisms to Clinical Differences.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Current use of anticholinergic medications in a large naturalistic sample of psychiatric patients.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Efficacy and safety of lamotrigine in the treatment of bipolar disorder across the lifespan: a systematic review.Therapeutic advances in psychopharmacology · 2021Review
- Real-world data on new users of atypical antipsychotics: characterisation, prescription patterns, healthcare costs and early cardio-metabolic occurrences from a large Italian database.European journal of clinical pharmacology · 2020Article
- Pharmacogenetic Testing Options Relevant to Psychiatry in Canada: Options de tests pharmacogénétiques pertinents en psychiatrie au Canada.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2020Review
- Prevalence and sort of pharmacokinetic drug-drug interactions in hospitalized psychiatric patients.Journal of neural transmission (Vienna, Austria : 1996) · 2020Article
- Clinically Significant Drug-Drug Interactions with Agents for Attention-Deficit/Hyperactivity Disorder.CNS drugs · 2019Review
- Complex polypharmacy in bipolar disorder: Side effect burden, adherence, and response predictors.Journal of affective disorders · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewPatients with bipolar disorder are frequently treated with polypharmacy. This article should provide clinicians with an understanding of how polypharmacy can contribute to pharmacokinetic and pharmacodynamic drug-drug interactions (DDIs). RECENT
findingsThe pharmacokinetics and pharmacodynamics of lithium and other mood stabilizers (valproate, lamotrigine, carbamazepine, oxcarbazepine, and eslicarbazepine), antipsychotics, and selective serotonin reuptake inhibitors (SSRIs) were reviewed and summarized in the first four tables describing their pharmacokinetic and pharmacodynamic mechanisms. Four tables summarized the DDIs which are likely to be clinically relevant in adults with bipolar disorder: two for mania treatments (with and without carbamazepine), one for maintenance treatments, and one for depression treatments. The purpose is to be practical, helping clinicians pay attention to and manage polypharmacy, avoiding adverse drug reactions (ADRs) in patients with bipolar disorder, including both the frequent ADRs and those rare but potentially lethal ADRs. Future articles should improve these tables.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.