Evidence map›Paper›PMID 29527594›Full record

ArticleJBMR plus2018

A Novel Distal Enhancer Mediates Inflammation-, PTH-, and Early Onset Murine Kidney Disease-Induced Expression of the Mouse

Melda Onal, Alex H Carlson, Jeff D Thostenson, Nancy A Benkusky, Mark B Meyer, Seong M Lee, J Wesley Pike

Open access · goldAbstract read
In one paragraph

Article in JBMR plus, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 59 citations in OpenAlex.

  1. Genome-wide association study of mature cow size traits in American Angus cattle.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Article
  2. TGFβ signaling regulates the response of the skeleton to phosphate.bioRxiv : the preprint server for biology · 2025
    Article
  3. Emerging concepts on the FGF23 regulation and activity.Molecular and cellular biochemistry · 2025
    Review
  4. Article
  5. Non-Classical Effects of FGF23: Molecular and Clinical Features.International journal of molecular sciences · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Approach to Hypophosphatemic Rickets.The Journal of clinical endocrinology and metabolism · 2022
    Article
  16. Review
  17. Article
  18. Review
  19. The regulation of FGF23 under physiological and pathophysiological conditions.Pflugers Archiv : European journal of physiology · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Melda OnalDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Alex H CarlsonDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Jeff D ThostensonDepartment of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Nancy A BenkuskyDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Mark B MeyerDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Seong M LeeDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
J Wesley PikeDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
University of Wisconsin–Madison · USUniversity of Arkansas for Medical Sciences · US

Funding

Training Program In Molecular AND Cellular PharmacologyT32GM008688 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI AUDHYA, ANJON · 1998 to 2020
$6.0M
Dynamic Mechanisms of Vitamin D-Induced Gene ExpressionR01DK072281 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI PIKE, J WESLEY · 2005 to 2012
$2.6M
Integrative genomics to define osteocyte differentiation, regulation and functionR01AR064424 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI PIKE, J WESLEY · 2014 to 2018
$1.7M
NIAMS NIH HHS R01 AR064424NIDDK NIH HHS R01 DK072281NIGMS NIH HHS T32 GM008688
6 · The paper itself

Abstract

Fibroblast growth factor 23 (FGF23) production is regulated by both calciotropic hormones and inflammation. Consistent with this, elevated FGF23 levels are associated with inflammatory markers as well as parathyroid hormone (PTH) in various disease states, including chronic kidney disease (CKD). However, the molecular mechanisms underpinning

Indexed as

CYTOKINESDISORDERS OF CALCIUM/PHOSPHATE METABOLISMGENETIC ANIMAL MODELSOSTEOCYTESPTH/VIT D/FGF23TRANSCRIPTIONAL REGULATION

Identifiers

PMID29527594
PMCPMC5842943
OpenAlexW2766078678

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.