ArticleChronic stress (Thousand Oaks, Calif.)
The role of stress in the pathogenesis and maintenance of obsessive-compulsive disorder.
Article in Chronic stress (Thousand Oaks, Calif.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 1 synthesis or guideline pooled it, 147 citations in OpenAlex.
- The COVID-19 pandemic and obsessive-compulsive disorder in young people: Systematic review.Clinical child psychology and psychiatry · 2022Pooled it
- Efficacy of the mHealth App Intellect in Improving Subclinical Obsessive-Compulsive Disorder in University Students: Randomized Controlled Trial With a 4-Week Follow-Up.JMIR mHealth and uHealth · 2024Trial
- A basolateral amygdala to dorsolateral striatum projection modulates stimulus-evoked motor behavior.Neuron · 2026Article
- Anxiety and Age, but Not OCD Diagnosis, Predict Infection-Preventive Behaviours in Adolescents During COVID-19.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2026Article
- Differential Ceramide Metabolism in Autogenous and Reactive Obsessions: A Biomarker Perspective in OCD.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026Article
- Article
- Why compulsions persist: An ecological momentary assessment study of the reinforcement of compulsions.Journal of affective disorders · 2026Article
- Lifetime Potentially Traumatic Events and Cognitive-Behavioral Therapy Outcomes in Pediatric Obsessive-Compulsive Disorder.JAACAP open · 2025Article
- Psychometric Evaluation of the Over-Cleanliness Scale (OCS) Amid Covid-19 Pandemic and the Role of Perceived Stress and OCD Proneness on Over-Cleanliness: A Cross-Sectional Study.Health science reports · 2025Article
- Classification of intrusive thought patterns based on differences in the mechanisms of occurrence and persistence.Frontiers in psychiatry · 2025Article
- Differential influence of habit components on compulsive and problematic reward-seeking behavior.PLOS mental health · 2025Article
- Deep brain stimulation for obsessive compulsive disorder leads to symptom changes of comorbid irritable bowel syndrome.Frontiers in psychiatry · 2025Article
- Impact of traumatic experiences on obsessive-compulsive disorder: a study of Palestinians in the Gaza Strip - a conflict area.European journal of psychotraumatology · 2024Article
- Psychosocial Impact of the COVID-19 Pandemic in Brazilian Post-Peak Period: Differences Between Individuals with and Without Pre-Existing Psychiatric Conditions.International journal of environmental research and public health · 2024Article
- Effects of chronic stress on cognitive function - From neurobiology to intervention.Neurobiology of stress · 2024Review
- Mechanisms of therapeutic change after psychedelic treatment in OCD.Psychiatry research · 2024Article
- Effort-reward imbalance and common mental disorders among public sector employees of Iran: a cross-sectional analysis.BMC public health · 2024Article
- Associations between somatomotor-putamen resting state connectivity and obsessive-compulsive symptoms vary as a function of stress during early adolescence: Data from the ABCD study.Brain research bulletin · 2024Article
- Opening new vistas on obsessive-compulsive disorder with the observing response task.Cognitive, affective & behavioral neuroscience · 2024Review
- Main Biological Models of Resilience.Clinical neuropsychiatry · 2024Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Individuals with OCD often identify psychosocial stress as a factor that exacerbates their symptoms, and many trace the onset of symptoms to a stressful period of life or a discrete traumatic incident. However, the pathophysiological relationship between stress and OCD remains poorly characterized: it is unclear whether trauma or stress is an independent cause of OCD symptoms, a triggering factor that interacts with a preexisting diathesis, or simply a nonspecific factor that can exacerbate OCD along with other aspects of psychiatric symptomatology. Nonetheless, preclinical research has demonstrated that stress has conspicuous effects on corticostriatal and limbic circuitry. Specifically, stress can lead to neuronal atrophy in frontal cortices (particularly the medial prefrontal cortex), the dorsomedial striatum (caudate), and the hippocampus. Stress can also result in neuronal hypertrophy in the dorsolateral striatum (putamen) and amygdala. These neurobiological effects mirror reported neural abnormalities in OCD and may contribute to an imbalance between goal-directed and habitual behavior, an imbalance that is implicated in the pathogenesis and expression of OCD symptomatology. The modulation of corticostriatal and limbic circuits by stress and the resultant imbalance between habit and goal-directed learning and behavior offers a framework for investigating how stress may exacerbate or trigger OCD symptomatology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.