ArticleChronic stress (Thousand Oaks, Calif.)
Chronic Stress in Adolescents and Its Neurobiological and Psychopathological Consequences: An RDoC Perspective.
Article in Chronic stress (Thousand Oaks, Calif.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it, 127 citations in OpenAlex.
- Punitive school discipline as a mechanism of structural marginalization with implications for health inequity: A systematic review of quantitative studies in the health and social sciences literature.Annals of the New York Academy of Sciences · 2023Pooled it
- The benefits of mindfulness training for momentary mindfulness and emotion regulation: A randomized controlled trial for adolescents exposed to chronic stressors.Journal of consulting and clinical psychology · 2024Trial
- Momentary effects of life stressors on mindfulness and emotion regulation difficulties among adolescents exposed to chronic stressors.Stress and health : journal of the International Society for the Investigation of Stress · 2024Trial
- Preventing Stress among High School Students in Denmark through the Multicomponent Healthy High School Intervention-The Effectiveness at First Follow-Up.International journal of environmental research and public health · 2023Trial
- Mindfulness augmentation for anxiety through concurrent use of transcranial direct current stimulation: a randomized double-blind study.Scientific reports · 2021Trial
- Beta-adrenergic blockade blunts inflammatory and antiviral/antibody gene expression responses to acute psychosocial stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Trial
- The indirect effect of peer problems on adolescent depression through nucleus accumbens volume alteration.Scientific reports · 2020Trial
- Blunted diurnal cortisol slope as a risk marker for 9-year executive function decline: amplification by daily stress and worry severity.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- Sex and stress paradigm influence behavioural, neuroimmune, and microbiome responses in pubertal CD-1 mice.Brain, behavior, & immunity - health · 2026Article
- Adolescent Stress Exposure: Behavioral Consequences and Molecular Mechanisms in Corticolimbic Networks.bioRxiv : the preprint server for biology · 2026Article
- Aperiodic Signatures of Stress Sensitivity and Depression Recurrence in Adolescents.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- The Role of Sleep in Mediating Mental Health Symptoms During the COVID-19 Pandemic in Children with and Without ADHD.Children (Basel, Switzerland) · 2026Article
- Adolescent stress exposure: behavioral consequences and molecular mechanisms in corticolimbic networks.Frontiers in cellular neuroscience · 2026Article
- The Research Domain Criteria (RDoC) domains positive valence system, negative valence system, cognitive systems, and social processes and their relationship with stress, anxiety, and depressive symptoms in a university student sample.Frontiers in psychiatry · 2026Article
- The impact of perceived parental conflict and school protective factors on chronic stress among Chinese adolescents: a network analysis perspective.Frontiers in psychology · 2026Article
- The relationship between household economic shocks, depression, and elevated stress-responsive biomarkers among adolescent girls and young women in rural South Africa (HPTN 068).Journal of affective disorders · 2025Article
- The role of neuroactive steroids in psychiatric and neurological disorders: Neurobiology and therapeutic perspectives.Neuroscience and biobehavioral reviews · 2025Review
- Subcortical functional connectivity alterations in first-episode medication-naïve adolescents with major depressive disorder.European child & adolescent psychiatry · 2025Article
- Alterations in Region-Specific Gray Matter Volume Underlying Callous Unemotional Traits in Adolescents.Brain and behavior · 2025Article
- Unraveling functional neurological disorder in pediatric populations: A systematic review of diagnosis, treatment, and outcomes.World journal of clinical pediatrics · 2025Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The Research Domain Criteria (RDoC) initiative provides a strategy for classifying psychopathology based on behavioral dimensions and neurobiological measures. Neurodevelopment is an orthogonal dimension in the current RDoC framework; however, it has not yet been fully incorporated into the RDoC approach. A combination of both a neurodevelopmental and RDoC approach offers a multidimensional perspective for understanding the emergence of psychopathology during development. Environmental influence (e.g., stress) has a profound impact on the risk for development of psychiatric illnesses. It has been shown that chronic stress interacts with the developing brain, producing significant changes in neural circuits that eventually increase the susceptibility for development of psychiatric disorders. This review highlights effects of chronic stress on the adolescent brain, as adolescence is a period characterized by a combination of significant brain alterations, high levels of stress, and emergence of psychopathology. The literature synthesized in this review suggests that chronic stress-induced changes in neurobiology and behavioral constructs underlie the shared vulnerability across a number of disorders in adolescence. The review particularly focuses on depression and substance use disorders; however, a similar argument can also be made for other psychopathologies, including anxiety disorders. The summarized findings underscore the need for a framework to integrate neurobiological findings from disparate psychiatric disorders and to target transdiagnostic mechanisms across disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.