Evidence map›Paper›PMID 29527570›Full record

ArticleACS biomaterials science & engineering2018

Synthesis of microgel sensors for spatial and temporal monitoring of protease activity.

Della S Shin, Emi Y Tokuda, Jennifer L Leight, Connor E Miksch, Tobin E Brown, Kristi S Anseth

Open access · greenAbstract read
In one paragraph

Article in ACS biomaterials science & engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Article
  3. Engineered hydrogels for mechanobiology.Nature reviews. Methods primers · 2022
    Article
  4. Boosting the Clinical Translation of Organ-on-a-Chip Technology.Bioengineering (Basel, Switzerland) · 2022
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Two-step deswelling in the Volume Phase Transition of thermoresponsive microgels.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  11. Organs-on-chips: into the next decade.Nature reviews. Drug discovery · 2021
    Review
  12. Review
  13. Article
  14. Article
  15. Enzymatic Cross-Linking of Dynamic Thiol-Norbornene Click Hydrogels.ACS biomaterials science & engineering · 2019
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Della S ShinDepartment of Chemical and Biological Engineering, University of Colorado at Boulder, 3415 Colorado Avenue, Boulder, CO 80309, USA.
Emi Y TokudaSuite 100, Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, 1100 Olive Way, Seattle, WA 98101, USA.
Jennifer L LeightDepartment of Biomedical Engineering, Ohio State University, 1080 Carmack Rd., Columbus, OH 43210, USA.
Connor E MikschDepartment of Chemical and Biological Engineering, University of Colorado at Boulder, 3415 Colorado Avenue, Boulder, CO 80309, USA.
Tobin E BrownDepartment of Chemical and Biological Engineering, University of Colorado at Boulder, 3415 Colorado Avenue, Boulder, CO 80309, USA.
Kristi S AnsethDepartment of Chemical and Biological Engineering, University of Colorado at Boulder, 3415 Colorado Avenue, Boulder, CO 80309, USA.
University of Colorado Boulder · USHoward Hughes Medical Institute · USSeattle Children's Hospital · USThe Ohio State University · US

Funding

Osteogenic Hydrogel Niches to Promote hMSC Migration and DifferentiationR01DE016523 · NIDCR · UNIVERSITY OF COLORADO AT BOULDER · PI ANSETH, KRISTI S. · 2005 to 2023
$6.2M
Protease Activity in 3D MatricesR21EB018505 · NIBIB · UNIVERSITY OF COLORADO · PI ANSETH, KRISTI S. · 2014 to 2015
$406k
Howard Hughes Medical InstituteNIBIB NIH HHS R21 EB018505NIDCR NIH HHS R01 DE016523
6 · The paper itself

Abstract

Proteases are involved in almost every important cellular activity, from embryonic morphogenesis to apoptosis. To study protease activity

Indexed as

3-dimensional cell culturecancerhydrogelsprotease sensorstumor remodeling

Identifiers

PMID29527570
PMCPMC5842818
OpenAlexW2595152890

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.