ArticleeNeuro
Sulcal Polymorphisms of the IFC and ACC Contribute to Inhibitory Control Variability in Children and Adults.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Protracted Functional and Structural Reorganization of Human Prefrontal Cortex Supports Lateralized Category Geometries.bioRxiv : the preprint server for biology · 2026Article
- Asymmetry of the sulcal pattern of the anterior cingulate cortex modulates delay discounting.Brain structure & function · 2026Article
- Sulcal anatomy of ventral temporal cortex and reading development.bioRxiv : the preprint server for biology · 2026Article
- Reassessing Asymmetry Reduction in Psychosis: Cingulate Folding and Gyrification Covariance in Patients with Auditory Hallucinations.Schizophrenia bulletin · 2026Article
- Variable Presence of an Evolutionarily New Brain Structure Is Related to Trait Impulsivity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Anchoring Functional Connectivity to Individual Sulcal Morphology Yields Insights in a Pediatric Study of Reasoning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Anchoring functional connectivity to individual sulcal morphology yields insights in a pediatric study of reasoning.bioRxiv : the preprint server for biology · 2025Article
- A self-supervised learning framework for discovering cortical folding patterns under genetic influence: Application to the Anterior Cingulate Cortex.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Variable Presence of an Evolutionarily New Brain Structure is Related to Trait Impulsivity.bioRxiv : the preprint server for biology · 2024Article
- Unique longitudinal contributions of sulcal interruptions to reading acquisition in children.bioRxiv : the preprint server for biology · 2024Article
- Are numerical abilities determined at early age? A brain morphology study in children and adolescents with and without developmental dyscalculia.Developmental cognitive neuroscience · 2024Article
- Structural and functional connectivity associations with anterior cingulate sulcal variability.Research square · 2024Article
- Orbitofrontal sulcal patterns in catatonia.European psychiatry : the journal of the Association of European Psychiatrists · 2023Article
- Development of cortical folds in the human brain: An attempt to review biological hypotheses, early neuroimaging investigations and functional correlates.Developmental cognitive neuroscience · 2023Review
- Sulcal depth in prefrontal cortex: a novel predictor of working memory performance.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Anterior cingulate sulcation is associated with onset and survival in frontotemporal dementia.Brain communications · 2023Article
- Cingulate cortex morphology impacts on neurofunctional activity and behavioral performance in interference tasks.Scientific reports · 2022Article
- Investigating the association between variability in sulcal pattern and academic achievement.Scientific reports · 2022Article
- Alpha desynchronization during Stroop test unmasks cognitively healthy individuals with abnormal CSF Amyloid/Tau.Neurobiology of aging · 2022Article
- Mother-child similarity in brain morphology: A comparison of structural characteristics of the brain's reading network.Developmental cognitive neuroscience · 2022Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 5 countries.
Funding
Abstract
Inhibitory control (IC) is a core executive function that enables humans to resist habits, temptations, or distractions. IC efficiency in childhood is a strong predictor of academic and professional success later in life. Based on analysis of the sulcal pattern, a qualitative feature of cortex anatomy determined during fetal life and stable during development, we searched for evidence that interindividual differences in IC partly trace back to prenatal processes. Using anatomical magnetic resonance imaging (MRI), we analyzed the sulcal pattern of two key regions of the IC neural network, the dorsal anterior cingulate cortex (ACC) and the inferior frontal cortex (IFC), which limits the inferior frontal gyrus. We found that the sulcal pattern asymmetry of both the ACC and IFC contributes to IC (Stroop score) in children and adults: participants with asymmetrical ACC or IFC sulcal patterns had better IC efficiency than participants with symmetrical ACC or IFC sulcal patterns. Such additive effects of IFC and ACC sulcal patterns on IC efficiency suggest that distinct early neurodevelopmental mechanisms targeting different brain regions likely contribute to IC efficiency. This view shares some analogies with the "common variant-small effect" model in genetics, which states that frequent genetic polymorphisms have small effects but collectively account for a large portion of the variance. Similarly, each sulcal polymorphism has a small but additive effect: IFC and ACC sulcal patterns, respectively, explained 3% and 14% of the variance of the Stroop interference scores.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.