ArticleEndoscopy international open2018
Linked color imaging enhances endoscopic detection of sessile serrated adenoma/polyps.
Article in Endoscopy international open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Linked color imaging versus conventional white-light colonoscopy for the detection of colorectal polyps.The Cochrane database of systematic reviews · 2025Pooled it
- Trial
- Trial
- Irrigating Acetic Acid Solution During Colonoscopy for the Detection of Sessile Serrated Neoplasia: A Randomized Controlled Trial.Digestive diseases and sciences · 2022Trial
- Efficacy of image-enhanced endoscopy for colorectal polyp detection.Clinical endoscopy · 2026Review
- Advancements and limitations of image-enhanced endoscopy in colorectal lesion diagnosis and treatment selection: A narrative review.DEN open · 2026Review
- Improvement of Colonoscopic Image Quality Using a New LED Endoscopic System with Specialized Noise Reduction.Diagnostics (Basel, Switzerland) · 2025Article
- The impact of linked color imaging on adenoma detection rate in colonoscopy: a systematic review and meta-analysis.Clinical endoscopy · 2025Article
- Linked color imaging for the detection and treatment of serrated colon neoplasia: current status and future perspective.Therapeutic advances in gastroenterology · 2025Review
- Endoscopic characteristics to differentiate SSLs and microvesicular hyperplastic polyps from goblet cell-rich hyperplastic polyps.Endoscopy international open · 2024Article
- Usefulness and safety of new ultrasmall-diameter colonoscope for cases with difficult insertion: a retrospective study.Scientific reports · 2024Article
- Advanced Imaging in Gastrointestinal Endoscopy: A Literature Review of the Current State of the Art.GE Portuguese journal of gastroenterology · 2023Review
- Usefulness of Acetic Acid Spray with Narrow-Band Imaging for Identifying the Margin of Sessile Serrated Lesions.Digestive diseases and sciences · 2023Article
- Detection of colorectal adenomas with texture and color enhancement imaging: Multicenter observational study.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2023Observational
- Evaluation of the detection rate of high‑grade gastric intraepithelial neoplasia using linked color imaging and white light imaging.Experimental and therapeutic medicine · 2023Article
- Image enhanced colonoscopy: updates and prospects-a review.Translational gastroenterology and hepatology · 2023Review
- Linked color imagingTherapeutic advances in gastroenterology · 2023Article
- Detection of colorectal lesions during colonoscopy.DEN open · 2022Review
- Visibility evaluation of colorectal lesion using texture and color enhancement imaging with video.DEN open · 2022Article
- TXI (Texture and Color Enhancement Imaging) for Serrated Colorectal Lesions.Journal of clinical medicine · 2021Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND STUDY
aimsAlthough new image-enhanced endoscopy (IEE) technologies such as blue laser imaging (BLI), BLI-bright, and linked color imaging (LCI) have been developed, their utility for the detection of sessile serrated adenoma/polyps (SSA/Ps) is still unclear. This study aimed to evaluate the utility of BLI, BLI-bright, and LCI for SSA/P detection in still image examinations and in a prospective randomized controlled trial (RCT). PATIENTS AND
methodsA group of 6 expert and non-expert endoscopists read 200 endoscopic still images containing SSA/P lesions using white light image (WLI), BLI, BLI-bright, and LCI. Color differences were calculated using the color space method. A prospective RCT of tandem colonoscopy with WLI and LCI was performed. Patients with SSA/P and those with a history of SSA/P that had been endoscopically removed were enrolled and randomly allocated to WLI-LCI or LCI-WLI groups. Additional endoscopic detection rates for SSA/P were compared between the 2 groups.
resultsLCI showed the highest SSA/P detection rate among the 4 modes for both expert and non-expert endoscopists. The detection rate with LCI for the 6 expert endoscopists (mean 98.3 ± standard deviation 2.0 %) was significantly higher than that with WLI (86.7 ± 6.0 %,
conclusionsLCI was the most sensitive mode for SSA/P detection among WLI, BLI, BLI-bright, and LCI in the still image examinations. Our RCT strongly suggests that LCI is superior to conventional WLI for SSA/P detection during colonoscopy. UMIN000017599.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.