Evidence map›Paper›PMID 29527544›Full record

ArticleData in brief2018

Data on genetic associations of carotid atherosclerosis markers in Mexican American and European American rheumatoid arthritis subjects.

Rector Arya, Agustin Escalante, Vidya S Farook, Jose F Restrepo, Daniel F Battafarano, Marcio Almeida, Mark Z Kos, Marcel J Fourcaudot, Srinivas Mummidi, Satish Kumar and 5 more

Open access · goldAbstract read
In one paragraph

Article in Data in brief, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. The effect of alpha-lipoic acid supplementation on vascular function and inflammation in patients newly experienced stroke.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Rector AryaDepartment of Human Genetics, School of Medicine, the University of Texas Rio Grande Valley, Edinburg/Brownsville, Texas, USA.
Agustin EscalanteDepartment of Medicine, Division of Rheumatology and Clinical Immunology, the University of Texas Health, San Antonio, Texas, USA.
Vidya S FarookDepartment of Human Genetics, School of Medicine, the University of Texas Rio Grande Valley, Edinburg/Brownsville, Texas, USA.
Jose F RestrepoDepartment of Medicine, Division of Rheumatology and Clinical Immunology, the University of Texas Health, San Antonio, Texas, USA.
Daniel F BattafaranoSan Antonio Military Medical Center, Fort Sam Houston, Texas, USA.
Marcio AlmeidaDepartment of Human Genetics, School of Medicine, the University of Texas Rio Grande Valley, Edinburg/Brownsville, Texas, USA.
Mark Z KosDepartment of Human Genetics, School of Medicine, the University of Texas Rio Grande Valley, Edinburg/Brownsville, Texas, USA.
Marcel J FourcaudotDivision of Diabetes, Department of Medicine, the University of Texas Health, San Antonio, Texas, USA.
Srinivas MummidiDepartment of Human Genetics, School of Medicine, the University of Texas Rio Grande Valley, Edinburg/Brownsville, Texas, USA.
Satish KumarDepartment of Human Genetics, School of Medicine, the University of Texas Rio Grande Valley, Edinburg/Brownsville, Texas, USA.
Joanne E CurranDepartment of Human Genetics, School of Medicine, the University of Texas Rio Grande Valley, Edinburg/Brownsville, Texas, USA.
Christopher P JenkinsonDepartment of Human Genetics, School of Medicine, the University of Texas Rio Grande Valley, Edinburg/Brownsville, Texas, USA.
John BlangeroDepartment of Human Genetics, School of Medicine, the University of Texas Rio Grande Valley, Edinburg/Brownsville, Texas, USA.
Ravindranath DuggiralaDepartment of Human Genetics, School of Medicine, the University of Texas Rio Grande Valley, Edinburg/Brownsville, Texas, USA.
Inmaculada Del RinconDepartment of Medicine, Division of Rheumatology and Clinical Immunology, the University of Texas Health, San Antonio, Texas, USA.
The University of Texas Rio Grande Valley · USThe University of Texas at San Antonio · USSan Antonio Military Medical Center · USThe University of Texas Health Science Center at San Antonio · US

Funding

INSTITUTE FOR INTEGRATION OF MEDICINE & SCIENCE: A PARTNERSHIP TO IMPROVE HEALTHUL1RR025767 · NCRR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A · 2008 to 2011
$23.8M
ZOLEDRONATE VS AREDIA IN MULTIPLE MYELOMA/BREAST CANCER W /BONE DISORDERSM01RR001346 · NCRR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ESCAMILLA, MICHAEL A · 1985 to 2008
$23.1M
The Disablement Process in Rheumatoid ArthritisR01HD037151 · NICHD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ESCALANTE, AGUSTIN · 1999 to 2011
$4.1M
Effect of Chronic Inflammation on Atherosclerosis Outcomes in RAR01HL085742 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DEL RINCON, INMACULADA · 2008 to 2013
$3.6M
Use and Outcome of Total Joint Replacement in HispanicsK24AR047530 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI ESCALANTE, AGUSTIN · 2001 to 2005
$682k
NCRR NIH HHS M01 RR001346NCRR NIH HHS UL1 RR025767NHLBI NIH HHS R01 HL085742NIAMS NIH HHS K24 AR047530NICHD NIH HHS R01 HD037151
6 · The paper itself

Abstract

Carotid Intima-media thickness (CIMT) and plaque are well established markers of subclinical atherosclerosis and are widely used for identifying subclinical atherosclerotic disease. We performed association analyses using Metabochip array to identify genetic variants that influence variation in CIMT and plaque, measured using B-mode ultrasonography, in rheumatoid arthritis (RA) patients. Data on genetic associations of common variants associated with both CIMT and plaque in RA subjects involving Mexican Americans (MA) and European Americans (EA) populations are presented in this article. Strong associations were observed after adjusting for covariate effects including baseline clinical characteristics and statin use. Susceptibility loci and genes and/or nearest genes associated with CIMT in MAs and EAs with RA are presented. In addition, common susceptibility loci influencing CIMT and plaque in both MAs and EAs have been presented. Polygenic Risk Score (PRS) plots showing complementary evidence for the observed CIMT and plaque association signals are also shown in this article. For further interpretation and details, please see the research article titled "A Genetic Association Study of Carotid Intima-Media Thickness (CIMT) and Plaque in Mexican Americans and European Americans with Rheumatoid Arthritis" which is being published in Atherosclerosis (Arya et al., 2018) [1].(Arya et al., in press) Thus, common variants in several genes exhibited significant associations with CIMT and plaque in both MAs and EAs as presented in this article. These findings may help understand the genetic architecture of subclinical atherosclerosis in RA populations.

Identifiers

PMID29527544
PMCPMC5842364
OpenAlexW2790564873

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.