ArticleSchizophrenia research. Cognition2018
Cognitive and psychopathology correlates of brain white/grey matter structure in severely psychotic schizophrenic inpatients.
Article in Schizophrenia research. Cognition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Cognitive subgroups of affective and non-affective psychosis show differences in medication and cortico-subcortical brain networks.Scientific reports · 2024Article
- Measures of Early-life Behavior and Later Psychopathology in the LifeCycle Project - EU Child Cohort Network: A Cohort Description.Journal of epidemiology · 2023Article
- Is there a causal relationship between executive function and liability to mental health and substance use? A Mendelian randomization approach.Royal Society open science · 2022Article
- Neurological Soft Signs Are Associated With Altered White Matter in Patients With Schizophrenia.Schizophrenia bulletin · 2022Article
- In vivo evidence of lower synaptic vesicle density in schizophrenia.Molecular psychiatry · 2021Article
- Psychopathological Syndromes Across Affective and Psychotic Disorders Correlate With Gray Matter Volumes.Schizophrenia bulletin · 2021Article
- Cognitive Implications of Correlated Structural Network Changes in Schizophrenia.Frontiers in integrative neuroscience · 2021Article
- Predictive timing disturbance is a precise marker of schizophrenia.Schizophrenia research. Cognition · 2018Article
- Confused Connections? Targeting White Matter to Address Treatment Resistant Schizophrenia.Frontiers in pharmacology · 2018Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brain structural correlates of cognitive and psychopathological symptoms within the active phase in severely psychotic schizophrenic inpatients have been rarely investigated. Twenty-eight inpatients with a DSM-5 diagnosis of Schizophrenia (SZ), admitted for acute psychotic decompensation, were assessed through a comprehensive neuropsychological and psychopathological battery. All patients underwent a high-resolution T1-weighted magnetic resonance imaging investigation. Increased psychotic severity was related to reduced grey matter volumes in the medial portion of the right superior frontal cortex, the superior orbitofrontal cortex bilaterally and to white matter volume reduction in the medial portion of the left superior frontal area. Immediate verbal memory performance was related to left insula and inferior parietal cortex volume, while long-term visuo-spatial memory was related to grey matter volume of the right middle temporal cortex, and the right (lobule VII, CRUS1) and left (lobule VI) cerebellum. Moreover, psychotic severity correlated with cognitive inflexibility and negative symptom severity was related to visuo-spatial processing and reasoning disturbances. These findings indicate that a disruption of the cortical-subcortical-cerebellar circuit, and distorted memory function contribute to the development and maintenance of psychotic exacerbation.
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