Evidence map›Paper›PMID 29527499›Full record

ArticleNeuroImage. Clinical2018

Visual processing deficits in 22q11.2 Deletion Syndrome.

Marjan Biria, Miralena I Tomescu, Anna Custo, Lucia M Cantonas, Kun-Wei Song, Maude Schneider, Micah M Murray, Stephan Eliez, Christoph M Michel, Tonia A Rihs

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

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  5. EEG microstate co-specificity in schizophrenia and obsessive-compulsive disorder.European archives of psychiatry and clinical neuroscience · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Marjan BiriaFunctional Brain Mapping Laboratory, Department of Fundamental Neuroscience, University Medical School, University of Geneva, Geneva, Switzerland.
Miralena I TomescuFunctional Brain Mapping Laboratory, Department of Fundamental Neuroscience, University Medical School, University of Geneva, Geneva, Switzerland.
Anna CustoFunctional Brain Mapping Laboratory, Department of Fundamental Neuroscience, University Medical School, University of Geneva, Geneva, Switzerland; EEG Brain Mapping Core, Center for Biomedical Imaging (CIBM) of Lausanne and Geneva, Lausanne, Switzerland.
Lucia M CantonasFunctional Brain Mapping Laboratory, Department of Fundamental Neuroscience, University Medical School, University of Geneva, Geneva, Switzerland.
Kun-Wei SongFunctional Brain Mapping Laboratory, Department of Fundamental Neuroscience, University Medical School, University of Geneva, Geneva, Switzerland.
Maude SchneiderDevelopmental Imaging and Psychopathology Laboratory, Department of Psychiatry, University of Geneva, Geneva, Switzerland.
Micah M MurrayThe Laboratory for Investigative Neurophysiology (The LINE), Neuropsychology and Neurorehabilitation Service and Department of Radiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland; EEG Brain Mapping Core, Center for Biomedical Imaging (CIBM) of Lausanne and Geneva, Lausanne, Switzerland; Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Ophthalmology, University of Lausanne, Fondation Asile des Aveugles, Lausanne, Switzerland.
Stephan EliezDevelopmental Imaging and Psychopathology Laboratory, Department of Psychiatry, University of Geneva, Geneva, Switzerland.
Christoph M MichelFunctional Brain Mapping Laboratory, Department of Fundamental Neuroscience, University Medical School, University of Geneva, Geneva, Switzerland; EEG Brain Mapping Core, Center for Biomedical Imaging (CIBM) of Lausanne and Geneva, Lausanne, Switzerland.
Tonia A RihsFunctional Brain Mapping Laboratory, Department of Fundamental Neuroscience, University Medical School, University of Geneva, Geneva, Switzerland. Electronic address: tonia.rihs@unige.ch.
University of Geneva · CHFondation Asile des Aveugles · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carriers of the rare 22q11.2 microdeletion present with a high percentage of positive and negative symptoms and a high genetic risk for schizophrenia. Visual processing impairments have been characterized in schizophrenia, but less so in 22q11.2 Deletion Syndrome (DS). Here, we focus on visual processing using high-density EEG and source imaging in 22q11.2DS participants (N = 25) and healthy controls (N = 26) with an illusory contour discrimination task. Significant differences between groups emerged at early and late stages of visual processing. In 22q11.2DS, we first observed reduced amplitudes over occipital channels and reduced source activations within dorsal and ventral visual stream areas during the P1 (100-125 ms) and within ventral visual cortex during the N1 (150-170 ms) visual evoked components. During a later window implicated in visual completion (240-285 ms), we observed an increase in global amplitudes in 22q11.2DS. The increased surface amplitudes for illusory contours at this window were inversely correlated with positive subscales of prodromal symptoms in 22q11.2DS. The reduced activity of ventral and dorsal visual areas during early stages points to an impairment in visual processing seen both in schizophrenia and 22q11.2DS. During intervals related to perceptual closure, the inverse correlation of high amplitudes with positive symptoms suggests that participants with 22q11.2DS who show an increased brain response to illusory contours during the relevant window for contour processing have less psychotic symptoms and might thus be at a reduced prodromal risk for schizophrenia.

Indexed as

AdolescentAdultAnalysis of VarianceBrain MappingCorrelation of DataDiGeorge SyndromeElectroencephalographyEvoked Potentials, VisualFemaleHumansMalePhotic StimulationProdromal SymptomsReaction TimeSeverity of Illness IndexTime Factors22q11.2 Deletion SyndromeBiomarkersHigh-density EEGIllusory contoursProdromal symptomsSchizophrenia

Identifiers

PMID29527499
PMCPMC5842759
OpenAlexW2777583830

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.