ArticleNeuroImage. Clinical2018
Risk for affective disorders is associated with greater prefrontal gray matter volumes: A prospective longitudinal study.
Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Brain structural correlates of familial risk for mental illness: a meta-analysis of voxel-based morphometry studies in relatives of patients with psychotic or mood disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Pooled it
- The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder.Biological psychiatry · 2019Pooled it
- Superior frontal and hippocampal structures associated with onset versus recurrence of mood disorders in monozygotic twins.Molecular psychiatry · 2026Article
- Neural correlates of acceptance and commitment therapy in major depressive disorder: a task-based fMRI study.Brain imaging and behavior · 2026Article
- Longitudinal Trajectory of Cognition, Brain Morphometry, and Brain Predicted Age in Unaffected First-Degree Relatives of Patients With Bipolar Disorder.Bipolar disorders · 2025Article
- Mapping Structural Neuroimaging Trajectories in Bipolar Disorder: Neurobiological and Clinical Implications.Biological psychiatry · 2025Review
- Early infant prefrontal gray matter volume is associated with concurrent and future infant emotionality.Translational psychiatry · 2023Article
- The inferior frontal gyrus and familial risk for bipolar disorder.Psychoradiology · 2022Review
- Associations Between Parental Mood and Anxiety Psychopathology and Offspring Brain Structure: A Scoping Review.Clinical child and family psychology review · 2022Article
- Hippocampal subfield morphology in monozygotic twins discordant for affective disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Aberrant structural covariance networks in youth at high familial risk for mood disorder.Bipolar disorders · 2020Article
- Profound and reproducible patterns of reduced regional gray matter characterize major depressive disorder.Translational psychiatry · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Major depression and bipolar disorders aggregates in families and are linked with a wide range of neurobiological abnormalities including cortical gray matter (GM) alterations. Prospective studies of individuals at familial risk may expose the neural mechanisms underlying risk transmission. Methods: We used voxel based morphometry to investigate changes in regional GM brain volume, over a seven-year period, in 37 initially healthy individuals having a mono- or di-zygotic twin diagnosed with major depression or bipolar disorder (high-risk group; mean age 41.6 yrs.) as compared to 36 individuals with no history of affective disorders in the index twin and first-degree relatives (low-risk group; mean age 38.5 yrs.). Results: Groups did not differ in regional GM volume changes over time. However, independent of time, high-risk twins had significantly greater GM volumes in bilateral dorsal anterior cingulate, inferior frontal gyrus and temporoparietal regions as compared to low-risk twins. Further, individuals who developed an affective disorder at follow-up (n = 12), had relatively the largest GM volumes, both at baseline and follow-up, in the right dorsal anterior cingulate cortex and right inferior frontal cortex compared to high- and low-risk twins who remained well at follow-up. Conclusion: This pattern of apparently stable grater regional GM volume may constitute a neural marker of an increased risk for developing an affective disorder in individuals at familial risk.
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