ArticleLubricants (Basel, Switzerland)2018
Phospholipid Vesicles in Media for Tribological Studies against Live Cartilage.
Article in Lubricants (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Ab Initio Insights into Zinc Dialkyldithiophosphate Linkage Isomers and Oxidative Degradation: Implications for Tribology.ACS applied nano materials · 2025Article
- Translational Characterization of Macrophage Responses to Stable and Non-Stable CoCrMo Wear and Corrosion Debris Generated In-Situ for Total Hip Replacement.Biotribology (Oxford) · 2023Article
- Morphological and Mechanical Characterization of Extracellular Vesicles and Parent Human Synoviocytes under Physiological and Inflammatory Conditions.International journal of molecular sciences · 2022Article
- Synovial Extracellular Vesicles: Structure and Role in Synovial Fluid Tribological Performances.International journal of molecular sciences · 2022Article
- The Implication of Reactive Oxygen Species and Antioxidants in Knee Osteoarthritis.Antioxidants (Basel, Switzerland) · 2021Review
- A MOVING CONTACT OF ARTICULATION ENHANCES THE BIOSYNTHETIC AND FUNCTIONAL RESPONSES OF ARTICULAR CARTILAGE.Biotribology (Oxford) · 2021Article
- Effects of Hyaluronan Molecular Weight on the Lubrication of Cartilage-Emulating Boundary Layers.Biomacromolecules · 2020Article
- Article
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Authors and funding
6 authors.
Funding
Abstract
introductionPre-clinical testing of hemiarthroplasty devices requires that the tribological conditions present in vivo with live cartilage be closely duplicated. A current limitation in the tribological testing of live cartilage involves the use of cell-culture media as lubricant. STUDY
aimto develop and test a new hyaluronan-phospholipid based medium (HA-phospholipid medium) that combines the rheological and frictional properties of synovial fluid with the nourishing properties of culture media to keep cells alive. MATERIALS AND
methodsThe HA-phospholipid medium consisted of culture medium with added phospholipid dipalmitoylphosphatidylcholine (0.3 mg/mL), and hyaluronic acid (2.42 mg/mL). A standard cell culture medium was used as the control. The rheology of each medium was determined using a flat plate configuration. Bovine calf cartilage was used to assess cell viability and friction in each medium. For friction measurements, a cobalt-chrome alloy ball was articulated against cartilage disks immersed in medium.
resultsLipid vesicles 0.1 to 50 μm in diameter were identified in the HA-phospholipid medium. Cartilage cell viability was significantly higher in the HA-phospholipid medium (62% ± 8%, 95% CI) than in control medium (49.5% ± 5%) (
conclusionsThe rheological and friction results indicate that the HA-phospholipid medium is superior to the control cell culture medium in emulating the shear thinning and lubricative properties of natural synovial fluid, making it more clinically relevant for in vitro wear and friction testing with live cartilage.
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