Evidence map›Paper›PMID 29527263›Full record

ArticleWorld journal of hepatology2018

Homologous recombination mediates stable Fah gene integration and phenotypic correction in tyrosinaemia mouse-model.

Norman Junge, Qinggong Yuan, Thu Huong Vu, Simon Krooss, Christien Bednarski, Asha Balakrishnan, Toni Cathomen, Michael P Manns, Ulrich Baumann, Amar Deep Sharma and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of hepatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Genome editing technologies to treat rare liver diseases.Translational gastroenterology and hepatology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Norman JungeDepartment of Pediatric Gastroenterology and Hepatology, Hannover Medical School, Hannover 30625, Germany.
Qinggong YuanDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover 30625, Germany.
Thu Huong VuDepartment of Pediatric Gastroenterology and Hepatology, Hannover Medical School, Hannover 30625, Germany.
Simon KroossTWINCORE, Centre for Experimental and Clinical Infection Research, Hannover 30625, Germany.
Christien BednarskiMedical Center, University of Freiburg, Institute for Cell and Gene Therapy, Freiburg 79108, Germany.
Asha BalakrishnanDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover 30625, Germany.
Toni CathomenMedical Center, University of Freiburg, Institute for Cell and Gene Therapy, Freiburg 79108, Germany.
Michael P MannsDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover 30625, Germany.
Ulrich BaumannDepartment of Pediatric Gastroenterology and Hepatology, Hannover Medical School, Hannover 30625, Germany.
Amar Deep SharmaDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover 30625, Germany.
Michael OttDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover 30625, Germany.
Medizinische Hochschule Hannover · DEUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo stably correct tyrosinaemia in proliferating livers of fumarylacetoacetate-hydrolase knockout (

methodsC57BL/6

resultsHere, we report successful HR-mediated genome editing by integration of a

conclusionHR-mediated

Indexed as

AAV8Gene therapyLiver based metabolic diseasePaediatric liver diseaseROSA26Targeted integration

Identifiers

PMID29527263
PMCPMC5838446
OpenAlexW2789287118

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.