ReviewWorld journal of hepatology2018
Glycogenic hepatopathy: A narrative review.
Review in World journal of hepatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 90 citations in OpenAlex.
- Mauriac Syndrome: Growth and Clinical Outcomes After 2.5 Years of Automated Insulin Delivery Treatment.JCEM case reports · 2026Article
- Hepatic Glycogenosis Resulting in Hyperammonemia in a Young Adult With Type 1 Diabetes Mellitus.JCEM case reports · 2026Article
- Glycogenic Hepatopathy: A Case Report of an Underdiagnosed Complication of Poorly Controlled Diabetes Mellitus.Clinical case reports · 2025Article
- Prevalence of liver disorders in children and adolescents with type 1 diabetes mellitus.BMC pediatrics · 2025Article
- Mauriac syndrome: a rare complication in patients with type 1 diabetes mellitus.Endocrinology, diabetes & metabolism case reports · 2025Article
- Hepatomegaly and Deranged Liver Enzymes in a Patient With Poorly Controlled Type 1 Diabetes Mellitus.JCEM case reports · 2025Article
- Hepatomegaly in an Adult With Type 1 Diabetes Mellitus: Mauriac Syndrome Still Exists in a Developed Country.JCEM case reports · 2025Article
- A Comprehensive Review of the Effects of Diabetes Mellitus on the Gastrointestinal System.Cureus · 2025Review
- Mauriac Syndrome in Sudanese Children: An Old Syndrome Still Existing in Resource-Limited Countries.Pediatric diabetes · 2025Article
- Type 1 Diabetes Mellitus with Diabetic Ketoacidosis Presenting with Transient Severe Fatty Liver and Subsequent Liver Dysfunction.Internal medicine (Tokyo, Japan) · 2024Article
- Article
- Compromised COPII vesicle trafficking leads to glycogenic hepatopathy.Disease models & mechanisms · 2024Article
- Characteristics, clinical laboratory, histopathology, and outcomes of glycogenic hepatopathy in children.JPGN reports · 2024Article
- Rapid improvement of severe fatty liver in a case of fulminant type 1 diabetes following insulin treatment.Diabetology international · 2024Article
- Persistent Lactatemia in Mauriac Syndrome.Case reports in endocrinology · 2024Article
- Article
- Persistent hyperlactatemia in decompensated type I diabetes with hepatic glycogenosis and hepatomegaly: Mauriac syndrome: a case report.Journal of medical case reports · 2022Article
- Aromatase Inhibition Eliminates Sexual Receptivity Without Enhancing Weight Gain in Ovariectomized Marmoset Monkeys.Journal of the Endocrine Society · 2022Article
- Hepatic Glycogenosis: An Underdiagnosed Entity?Cureus · 2022Article
- A Case of Glycogenic Hepatopathy as a Complication of Poorly Controlled Type 1 Diabetes Mellitus.Case reports in endocrinology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glycogenic hepatopathy (GH) is a rare complication of the poorly controlled diabetes mellitus characterized by the transient liver dysfunction with elevated liver enzymes and associated hepatomegaly caused by the reversible accumulation of excess glycogen in the hepatocytes. It is predominantly seen in patients with longstanding type 1 diabetes mellitus and rarely reported in association with type 2 diabetes mellitus. Although it was first observed in the pediatric population, since then, it has been reported in adolescents and adults with or without ketoacidosis. The association of GH with hyperglycemia in diabetes has not been well established. One of the essential elements in the pathophysiology of development of GH is the wide fluctuation in both glucose and insulin levels. GH and non-alcoholic fatty liver disease (NAFLD) are clinically indistinguishable, and latter is more prevalent in diabetic patients and can progress to advanced liver disease and cirrhosis. Gradient dual-echo MRI can distinguish GH from NAFLD; however, GH can reliably be diagnosed only by liver biopsy. Adequate glycemic control can result in complete remission of clinical, laboratory and histological abnormalities. There has been a recent report of varying degree of liver fibrosis identified in patients with GH. Future studies are required to understand the biochemical defects underlying GH, noninvasive, rapid diagnostic tests for GH, and to assess the consequence of the fibrosis identified as severe fibrosis may progress to cirrhosis. Awareness of this entity in the medical community including specialists is low. Here we briefly reviewed the English literature on pathogenesis involved, recent progress in the evaluation, differential diagnosis, and management.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.