Evidence map›Paper›PMID 29527204›Full record

ArticleFrontiers in immunology2018

Clinical, Immunological, and Molecular Findings in Five Patients with Major Histocompatibility Complex Class II Deficiency from India.

Jahnavi Aluri, Maya Gupta, Aparna Dalvi, Snehal Mhatre, Manasi Kulkarni, Gouri Hule, Mukesh Desai, Nitin Shah, Prasad Taur, Ramprasad Vedam and 1 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Helper T cell immunity in humans with inherited CD4 deficiency.The Journal of experimental medicine · 2024
    Article
  8. Class II Transactivator Gene (The application of clinical genetics · 2024
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Case Report: Novel splicing mutations inFrontiers in genetics · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Jahnavi AluriDepartment of Pediatric Immunology and Leukocyte Biology, National Institute of Immunohaematology (ICMR), Mumbai, India.
Maya GuptaDepartment of Pediatric Immunology and Leukocyte Biology, National Institute of Immunohaematology (ICMR), Mumbai, India.
Aparna DalviDepartment of Pediatric Immunology and Leukocyte Biology, National Institute of Immunohaematology (ICMR), Mumbai, India.
Snehal MhatreDepartment of Pediatric Immunology and Leukocyte Biology, National Institute of Immunohaematology (ICMR), Mumbai, India.
Manasi KulkarniDepartment of Pediatric Immunology and Leukocyte Biology, National Institute of Immunohaematology (ICMR), Mumbai, India.
Gouri HuleDepartment of Pediatric Immunology and Leukocyte Biology, National Institute of Immunohaematology (ICMR), Mumbai, India.
Mukesh DesaiDivision of Immunology, Bai Jerbai Wadia Hospital for Children, Mumbai, India.
Nitin ShahPediatric Hematology-Oncology, P. D. Hinduja National Hospital & Research Center, Mumbai, India.
Prasad TaurDivision of Immunology, Bai Jerbai Wadia Hospital for Children, Mumbai, India.
Ramprasad VedamMedgenome Labs Pvt. Ltd., Bangalore, India.
Manisha MadkaikarDepartment of Pediatric Immunology and Leukocyte Biology, National Institute of Immunohaematology (ICMR), Mumbai, India.
National Institute of Immunohaematology · INBai Jerbai Wadia Hospital for Children · INNational Hospital · INSciGenom Labs (India) · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Major histocompatibility complex (MHC) class II deficiency is a rare autosomal recessive form of primary immunodeficiency disorder (PID) characterized by the deficiency of MHC class II molecules. This deficiency affects the cellular and humoral immune response by impairing the development of CD4

Indexed as

MutationAntibody FormationFatal OutcomeFemaleGastrointestinal DiseasesHematopoietic Stem Cell TransplantationHistocompatibility Antigens Class IIHLA-D AntigensHumansImmunologic Deficiency SyndromesIndiaInfantMaleNuclear ProteinsRegulatory Factor X Transcription FactorsRespiratory Tract InfectionsHistocompatibility Antigens Class IIHLA-D AntigensMHC class II transactivator proteinNuclear ProteinsRegulatory Factor X Transcription FactorsRFX5 protein, humanTrans-Activatorsflow cytometryhematopoietic stem cell transplantationnext-generation sequencingprimary immunodeficiency disorderT cell receptor excision circles

Identifiers

PMID29527204
PMCPMC5829618
OpenAlexW2790279588

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.