Evidence map›Paper›PMID 29527142›Full record

ArticleInternational journal of peptide research and therapeutics2018

Modulation of Oral Bioavailability and Metabolism for Closely Related Cyclic Hexapeptides.

Thomas Vorherr, Ian Lewis, Joerg Berghausen, Sandrine Desrayaud, Michael Schaefer

Abstract read
In one paragraph

Article in International journal of peptide research and therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. The Unusual Role of Pro in Cu(II) Binding by HisInternational journal of molecular sciences · 2021
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Thomas VorherrNovartis Institutes for Biomedical Research, 4002 Basel, Switzerland.ORCID 0000-0001-7346-2693
Ian LewisNovartis Institutes for Biomedical Research, 4002 Basel, Switzerland.
Joerg BerghausenNovartis Institutes for Biomedical Research, 4002 Basel, Switzerland.
Sandrine DesrayaudNovartis Institutes for Biomedical Research, 4002 Basel, Switzerland.
Michael SchaeferNovartis Institutes for Biomedical Research, 4002 Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abstractRecently, a variety of studies concerned with the permeability and oral bioavailability of cyclic peptides have been reported. In particular, strategies aiming at modifying peptides to maintain or to enhance solubility while enabling permeability constitute a significant challenge, but are of high interest to ensure a smooth drug discovery process. Current methodologies include GRAPHICAL ABSTRACT:

Indexed as

ConformationOral bioavailabilityPeptide metabolismPermeabilityPharmacokinetics

Identifiers

PMID29527142
PMCPMC5838147

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.