ReviewEye (London, England)2018
Space flight-associated neuro-ocular syndrome (SANS).
Review in Eye (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it, 154 citations in OpenAlex.
- Effect of spaceflight experience on human brain structure, microstructure, and function: systematic review of neuroimaging studies.Brain imaging and behavior · 2024Pooled it
- Women in space: A review of known physiological adaptations and health perspectives.Experimental physiology · 2026Review
- A computational model of altered neuronal activity in altered gravity.NPJ microgravity · 2026Article
- Astronauts of the US National Aeronautics and Space Administration (NASA): cohort profile.BMJ open · 2026Article
- Ophthalmic and Visual System Changes in Human Spaceflight: A Review of Mechanisms, Measurement, and Countermeasures.Journal of clinical medicine · 2026Review
- Optic nerve cerebrospinal fluid drainage via lymphatic vessels in its sheath.NPJ microgravity · 2026Article
- Influence of hydrostatic gradients and diurnal rhythm on cerebral and ocular blood flow.European journal of applied physiology · 2026Article
- Submarine medicine as an analog for spaceflight: a review of acute medical care.NPJ microgravity · 2026Review
- Integrative cardiovascular dose-response to graded lower-body negative pressure.Experimental physiology · 2025Article
- Artificial Intelligence Deep Learning Models to Predict Spaceflight Associated Neuro-Ocular Syndrome.American journal of ophthalmology · 2025Article
- Non invasive monitoring for spaceflight associated neuro ocular syndrome: responding to a need for In flight methodologies.NPJ microgravity · 2025Article
- Analysis of Spaceflight-Associated Biometric and Refractive Changes in Astronauts.American journal of ophthalmology · 2025Article
- Brains in space: impact of microgravity and cosmic radiation on the CNS during space exploration.Nature reviews. Neuroscience · 2025Review
- Spatial and Temporal Changes in Choroid Morphology Associated With Long-Duration Spaceflight.Investigative ophthalmology & visual science · 2025Article
- Could Sleep Be an Antidote to Optic Disc Edema in Astronauts?Life (Basel, Switzerland) · 2025Article
- Impact of microgravity on retinal neuroimmune responses and visual dysfunction in rats.International journal of ophthalmology · 2025Article
- Hypothesis on the outflow of optic nerve cerebrospinal fluid in spaceflight associated neuro ocular syndrome.NPJ microgravity · 2024Review
- Otoacoustic Estimate of Astronauts' Intracranial Pressure Changes During Spaceflight.Journal of the Association for Research in Otolaryngology : JARO · 2024Article
- Artificial Gravity Attenuates the Transcriptomic Response to Spaceflight in the Optic Nerve and Retina.International journal of molecular sciences · 2024Article
- Refractive shifts in astronauts during spaceflight: mechanisms, countermeasures, and future directions for in-flight measurements.Eye (London, England) · 2024Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interesting novel and somewhat perplexing physiologic and pathologic neuro-ocular findings have been documented in astronauts during and after long duration space flight (LDSF). These findings collectively have been termed the "space flight-associated neuro-ocular syndrome" (SANS). The National Aeronautics and Space Administration (NASA) in the United States has meticulously and prospectively documented the clinical, ultrasound, optical coherence tomography imaging, and radiographic findings of SANS including unilateral and bilateral optic disc edema, globe flattening, choroidal and retinal folds, hyperopic refractive error shifts, and nerve fiber layer infarcts (i.e., cotton wool spots). NASA and collaborating researchers continue to study SANS in preparation for future manned missions to space, including continued trips to the ISS, a return to the moon, or perhaps new voyages to the asteroid belt, or the planet, Mars.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.