Evidence map›Paper›PMID 29527006›Full record

ArticleTranslational psychiatry2018

Genome-wide analyses of self-reported empathy: correlations with autism, schizophrenia, and anorexia nervosa.

Varun Warrier, Roberto Toro, Bhismadev Chakrabarti, iPSYCH-Broad autism group, Anders D Børglum, Jakob Grove, 23andMe Research Team, David A Hinds, Thomas Bourgeron, Simon Baron-Cohen

Open access · goldAbstract read
In one paragraph

Article in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 137 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 4 countries.

Varun WarrierDepartment of Psychiatry, Autism Research Centre, University of Cambridge, Cambridgeshire, UK. vw260@medschl.cam.ac.uk.
Roberto ToroHuman Genetics and Cognitive Functions Unit, Institut Pasteur, Paris, France.ORCID http://orcid.org/0000-0002-6671-858X
Bhismadev ChakrabartiDepartment of Psychiatry, Autism Research Centre, University of Cambridge, Cambridgeshire, UK.ORCID http://orcid.org/0000-0002-6649-7895
iPSYCH-Broad autism group
Anders D BørglumThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.
Jakob GroveThe Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Aarhus, Denmark.
23andMe Research Team
David A Hinds23andMe, Inc., Mountain View, CA, 94041, USA.
Thomas BourgeronHuman Genetics and Cognitive Functions Unit, Institut Pasteur, Paris, France.
Simon Baron-CohenDepartment of Psychiatry, Autism Research Centre, University of Cambridge, Cambridgeshire, UK. sb205@cam.ac.uk.
Aarhus University · DKCentre National de la Recherche Scientifique · FRUniversity of Cambridge · GB

Funding

Development of a web-based database and research engine for genetic discoveryR44HG006981 · NHGRI · 23ANDME, INC. · PI MOUNTAIN, JOANNA L. · 2013 to 2014
$1.4M
Department of HealthMedical Research CouncilNHGRI NIH HHS R44 HG006981Wellcome Trust
6 · The paper itself

Abstract

Empathy is the ability to recognize and respond to the emotional states of other individuals. It is an important psychological process that facilitates navigating social interactions and maintaining relationships, which are important for well-being. Several psychological studies have identified difficulties in both self-report and performance-based measures of empathy in a range of psychiatric conditions. To date, no study has systematically investigated the genetic architecture of empathy using genome-wide association studies (GWAS). Here we report the results of the largest GWAS of empathy to date using a well-validated self-report measure of empathy, the Empathy Quotient (EQ), in 46,861 research participants from 23andMe, Inc. We identify 11 suggestive loci (P < 1 × 10

Indexed as

Genome-Wide Association StudyAdultAnorexia NervosaAutism Spectrum DisorderEmpathyExtraversion, PsychologicalFemaleHumansMalePersonalityPolymorphism, Single NucleotideSchizophrenia

Identifiers

PMID29527006
PMCPMC5845860
OpenAlexW2770116496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.