ArticleThe Journal of veterinary medical science2018
The mechanisms underlying the effects of AMH on Müllerian duct regression in male mice.
Article in The Journal of veterinary medical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 13 citations in OpenAlex.
- Developmental disorders of the reproductive tract in C57BL/6N-XYThe Journal of veterinary medical science · 2026Article
- Establishment of an organ culture system to maintain the structure of mouse Müllerian ducts during development.The Journal of veterinary medical science · 2024Article
- Mini review: Asymmetric Müllerian duct development in the chicken embryo.Frontiers in cell and developmental biology · 2024Review
- Effect of AMH on primordial follicle populations in mouse ovaries and human pre-pubertal ovarian xenografts during doxorubicin treatment.Frontiers in cell and developmental biology · 2024Article
- Expression patterns of sex steroid receptors in developing mesonephros of the male mouse: three-dimensional analysis.Cell and tissue research · 2023Article
- Partial male-to-female reprogramming of mouse fetal testis by Sertoli cell ablation.Development (Cambridge, England) · 2023Article
- Anatomy and histology of the foramen of ovarian bursa opening to the peritoneal cavity and its changes in autoimmune disease-prone mice.Journal of anatomy · 2021Article
- Establishment of an organ culture system to induce Sertoli cell differentiation from undifferentiated mouse gonads.The Journal of veterinary medical science · 2020Article
- Genetic differences between C57BL/6 substrains affect the process of testis differentiation in YThe Journal of veterinary medical science · 2019Article
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anti-Müllerian hormone (AMH) produced in the developing testis induces the regression of the Müllerian duct, which develops into the oviducts, uterus and upper vagina. In our true hermaphrodite mouse with an ovary on one side and a testis on the other (O/T), the oviduct and uterus are present only on the ovary side, and nothing derived from the Müllerian duct is present on the testis side. Here, we investigate the mechanism underlying the unilateral Müllerian duct regression and the mode of AMH signaling, by performing immunohistology, Western blotting, and organ culture analyses. The histological analysis revealed that during the start of the Müllerian duct regression, the duct in the O/T mice was clearly regressed on the AMH-positive testis side compared to the AMH-negative ovary side. The immunohistochemistry showed a diffuse immunoreaction of AMH in the interstitium surrounding the testis cord and boundary region between the testis and mesonephros, especially in the cranial portion. Western blotting revealed that the amount of AMH in the cranial half of the mesonephros was larger than that in the caudal half. AMH injected into the gonads in organ culture induced the regression of the Müllerian duct via the interstitium of the organ. These results suggest that AMH acts on the Müllerian duct in male mice by exuding into the interstitium surrounding the testis cord and infiltrating through the cranial region from the testis to the mesonephros.
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