ArticleRestorative neurology and neuroscience2018
Paired associative stimulation modulates corticomotor excitability in chronic stroke: A preliminary investigation.
Article in Restorative neurology and neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Repetitive peripheral magnetic stimulation alone or in combination with repetitive transcranial magnetic stimulation in poststroke rehabilitation: a systematic review and meta-analysis.Journal of neuroengineering and rehabilitation · 2024Pooled it
- Repetitive peripheral magnetic stimulation combined with transcranial magnetic stimulation in rehabilitation of upper extremity hemiparesis following stroke: a pilot study.Journal of rehabilitation medicine · 2024Trial
- Visuomotor paired associative stimulation enhances corticospinal excitability in post-stroke patients with upper-limb hemiparesis.Scientific reports · 2025Article
- The Effectiveness of Paired Associative Stimulation on Motor Recovery after Stroke: A Scoping Review.Neurology international · 2024Article
- Cortical Sensorimotor Integration as a Neural Origin of Impaired Grip Force Direction Control following Stroke.Brain sciences · 2024Article
- Knowledge and attitude toward transcranial magnetic stimulation among rehabilitation specialists in Saudi Arabia.Frontiers in bioengineering and biotechnology · 2024Article
- Targeted Modulation of Human Brain Interregional Effective Connectivity With Spike-Timing Dependent Plasticity.Neuromodulation : journal of the International Neuromodulation Society · 2023Article
- Repetitive Transcranial Magnetic Stimulation of the Brain After Ischemic Stroke: Mechanisms from Animal Models.Cellular and molecular neurobiology · 2023Review
- Noninvasive Brain Stimulation for Neurorehabilitation in Post-Stroke Patients.Brain sciences · 2023Review
- Top-down and bottom-up stimulation techniques combined with action observation treatment in stroke rehabilitation: a perspective.Frontiers in neurology · 2023Review
- The effect of paired associative stimulation with a high-intensity cortical component and a high-frequency peripheral component on heart rate and heart rate variability in healthy subjects.Frontiers in rehabilitation sciences · 2023Article
- Changes in somatosensory evoked potentials elicited by lateral cerebellar nucleus deep brain stimulation in the naïve rodent.Neuroscience letters · 2022Article
- Neurostimulation for Stroke Rehabilitation.Frontiers in neuroscience · 2021Review
- Temporal Profile of Descending Cortical Modulation of Spinal Excitability: Group and Individual-Specific Effects.Frontiers in integrative neuroscience · 2021Article
- Targeting Sensory and Motor Integration for Recovery of Movement After CNS Injury.Frontiers in neuroscience · 2021Review
- Paired Associative Stimulation as a Tool to Assess Plasticity Enhancers in Chronic Stroke.Frontiers in neuroscience · 2019Article
- Modulatory Effects of Motor State During Paired Associative Stimulation on Motor Cortex Excitability and Motor Skill Learning.Frontiers in human neuroscience · 2019Article
- Shaping the Effects of Associative Brain Stimulation by Contractions of the Opposite Limb.Frontiers in psychology · 2018Article
- Article
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3 authors.
Funding
Abstract
backgroundPaired associative stimulation (PAS) combining repeated pairing of electrical stimulation of a peripheral nerve with transcranial magnetic stimulation (TMS) over the primary motor cortex (M1) can induce neuroplastic adaptations in the human brain and enhance motor learning in neurologically-intact individuals. However, the extent to which PAS is an effective technique for inducing associative plasticity and improving motor function in individuals post-stroke is unclear.
objectiveThe objective of this pilot study was to investigate the effects of a single session of PAS to modulate corticomotor excitability and motor skill performance in individuals post-stroke.
methodsSeven individuals with chronic stroke completed two separate visits separated by at least one week. We assessed general corticomotor excitability, intracortical network activity and behavioral outcomes prior to and at three time points following PAS and compared these outcomes to those following a sham PAS condition (PASSHAM).
resultsFollowing PAS, we found increased general corticomotor excitability but no significant difference in behavioral measures between PAS conditions. There was a relationship between PAS-induced corticomotor excitability increase and enhanced motor skill performance across post-PAS testing time points.
conclusionThese results provide preliminary evidence for the potential of PAS to increase corticomotor excitability that could favorably impact motor skill performance in chronic individuals post-stroke and are an important first step for future studies investigating the clinical application and behavioral relevance of PAS interventions in post stroke patient populations.
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