Evidence map›Paper›PMID 29526809›Full record

ArticleFree radical biology & medicine2018

An innate immune response and altered nuclear receptor activation defines the spinal cord transcriptome during alpha-tocopherol deficiency in Ttpa-null mice.

Carrie J Finno, Matthew H Bordbari, Giuliana Gianino, Brittni Ming-Whitfield, Erin Burns, Janel Merkel, Monica Britton, Blythe Durbin-Johnson, Erica A Sloma, Marissa McMackin and 9 more

Abstract read
In one paragraph

Article in Free radical biology & medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Enjoy Carefully: The Multifaceted Role of Vitamin E in Neuro-Nutrition.International journal of molecular sciences · 2021
    Review
  4. Article
  5. Article
  6. Article
  7. Breeder Diet Strategies for GeneratingCurrent developments in nutrition · 2020
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Carrie J FinnoDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, United States. Electronic address: cjfinno@ucdavis.edu.
Matthew H BordbariDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, United States.
Giuliana GianinoDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, United States.
Brittni Ming-WhitfieldDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, United States.
Erin BurnsDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, United States.
Janel MerkelDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, United States.
Monica BrittonBioinformatics Core Facility, Genome Center, University of California, Davis, CA 95616, United States.
Blythe Durbin-JohnsonBioinformatics Core Facility, Genome Center, University of California, Davis, CA 95616, United States.
Erica A SlomaDepartment of Biomedical Sciences, Section of Anatomic Pathology, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, United States.
Marissa McMackinDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, United States.
Gino CortopassiDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, United States.
Victor RivasDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, United States.
Marietta BarroDepartment of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, United States.
Cecilia K TranDepartment of Medicinal Chemistry, University of Washington, Seattle, WA 98195, United States.
Ingrid GennityDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, United States.
Hadi HabibDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, United States.
Libin XuDepartment of Medicinal Chemistry, University of Washington, Seattle, WA 98195, United States.
Birgit PuschnerDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, United States.
Andrew D MillerDepartment of Biomedical Sciences, Section of Anatomic Pathology, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, United States.
University of California, Davis · USCornell University · USUniversity of Washington · US

Funding

Oxysterols in SLOS Neurodevelopment: Pathological Role and TherapyR01HD092659 · NICHD · UNIVERSITY OF WASHINGTON · PI XU, LIBIN · 2017 to 2021
$1.9M
7-Dehydrocholesterol-derived oxysterols in SLOS: role and therapyR00HD073270 · NICHD · UNIVERSITY OF WASHINGTON · PI XU, LIBIN · 2015 to 2017
$745k
Molecular pathogenesis of alpha-tocopherol associated neuroaxonal dystrophy in anK01OD015134 · OD · UNIVERSITY OF MINNESOTA · PI FINNO, CARRIE · 2013 to 2017
$599k
NCATS NIH HHS L40 TR001136NICHD NIH HHS R00 HD073270NICHD NIH HHS R01 HD092659NIH HHS K01 OD015134
6 · The paper itself

Abstract

Mice with deficiency in tocopherol (alpha) transfer protein gene develop peripheral tocopherol deficiency and sensory neurodegeneration. Ttpa

Indexed as

Nerve Degenerationalpha-TocopherolAnimalsCarrier ProteinsCerebellumFemaleImmunity, InnateLiver X ReceptorsMaleMiceMice, KnockoutSpinal CordTranscriptomeVitamin E Deficiencyalpha-Tocopherolalpha-tocopherol transfer proteinCarrier ProteinsLiver X ReceptorsRNA-sequencingTranscriptionVitamin E

Identifiers

PMID29526809
PMCPMC5940542
OpenAlexW2793823516

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.