Evidence map›Paper›PMID 29526695›Full record

ArticleMolecular cell2018

The 3.5-Å CryoEM Structure of Nanodisc-Reconstituted Yeast Vacuolar ATPase V

Soung-Hun Roh, Nicholas J Stam, Corey F Hryc, Sergio Couoh-Cardel, Grigore Pintilie, Wah Chiu, Stephan Wilkens

Open access · bronzeAbstract readVideo-Audio Media
In one paragraph

Article in Molecular cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 121 citations in OpenAlex.

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  9. NaNature structural & molecular biology · 2025
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  11. ModelingJournal of cellular immunology · 2025
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  12. Structure of yeast RAVE bound to a partial VProceedings of the National Academy of Sciences of the United States of America · 2024
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  15. Eukaryotic yeast VFrontiers in molecular biosciences · 2024
    Article
  16. Article
  17. Tender love and disassembly: How a TLDc domain protein breaks the V-ATPase.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023
    Article
  18. Article
  19. Article
  20. Structural and Functional Diversity of Two ATP-Driven Plant Proton Pumps.International journal of molecular sciences · 2023
    Review

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Soung-Hun RohDepartment of Bioengineering and James H. Clark Center, Stanford University, Stanford, CA 94305, USA; Biosciences Division, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA.
Nicholas J StamDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Corey F HrycGraduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX 77030, USA; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Sergio Couoh-CardelDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Grigore PintilieVerna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Wah ChiuDepartment of Bioengineering and James H. Clark Center, Stanford University, Stanford, CA 94305, USA; Biosciences Division, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA; Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: wahc@stanford.edu.
Stephan WilkensDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA. Electronic address: wilkenss@upstate.edu.
SUNY Upstate Medical University · USBaylor College of Medicine · USSLAC National Accelerator Laboratory · US

Funding

TRAINING PROGRAM IN COMPUTATIONAL BIOLOGY AND MEDICINET15LM007093 · NLM · RICE UNIVERSITY · PI Lydia E. Kavraki · 1992 to 2026
$20.8M
3 D ELECTRON MICROSCOPY OF MACROMOLECULES (5P41RR002250-27)P41GM103832 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH · 2012 to 2019
$15.1M
Unified Data Resource for Large Complexes Determined by Cryo-Electron MicroscopyR01GM079429 · NIGMS · STANFORD UNIVERSITY · PI CHIU, WAH · 2007 to 2021
$11.6M
STRUCTURE OF THE VACUOLAR ATPASE BY ELECTRON MICROSCOPYR01GM058600 · NIGMS · UPSTATE MEDICAL UNIVERSITY · PI WILKENS, STEPHAN · 1999 to 2020
$4.8M
NIGMS NIH HHS P41 GM103832NIGMS NIH HHS R01 GM058600NIGMS NIH HHS R01 GM079429NLM NIH HHS T15 LM007093
6 · The paper itself

Abstract

The molecular mechanism of transmembrane proton translocation in rotary motor ATPases is not fully understood. Here, we report the 3.5-Å resolution cryoEM structure of the lipid nanodisc-reconstituted V

Indexed as

Cryoelectron MicroscopyNanoparticlesGenotypeHumansMembrane LipidsModels, MolecularMutationPhenotypeProtein Conformation, alpha-HelicalProtein Interaction Domains and MotifsProtein MultimerizationProtein SubunitsProtonsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsStructure-Activity RelationshipATP6V0A1 protein, humanMembrane LipidsProtein SubunitsProtonsSaccharomyces cerevisiae ProteinsVacuolar Proton-Translocating ATPasesVOA1 protein, S cerevisiaecryoEMlipid nanodiscmembrane protein structureproton pumpingreversible disassemblyvacuolar H(+)-ATPaseV-ATPase assemblyVoa1V(o) proton channel

Identifiers

PMID29526695
PMCPMC5893162
OpenAlexW2794082753

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.