ArticleReproductive toxicology (Elmsford, N.Y.)2018
Low dose bisphenol S or ethinyl estradiol exposures during the perinatal period alter female mouse mammary gland development.
Article in Reproductive toxicology (Elmsford, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Pooled it
- Integrating human biomonitoring into food safety risk assessment: Advances, challenges, and future perspectives.Current research in food science · 2026Review
- In utero exposure to estrogenic bisphenol analogues increases mammary tissue stiffness.Reproductive toxicology (Elmsford, N.Y.) · 2025Article
- Mitigating Dietary Bisphenol Exposure Through the Gut Microbiota: The Role of Next-Generation Probiotics in Bacterial Detoxification.Nutrients · 2024Review
- Maternal Bisphenol B Exposure and Mammary Gland Development of Offspring: A Time-Series Analysis.Environment & health (Washington, D.C.) · 2023Article
- Chemical Effects on Breast Development, Function, and Cancer Risk: Existing Knowledge and New Opportunities.Current environmental health reports · 2022Review
- Best practices to quantify the impact of reproductive toxicants on development, function, and diseases of the rodent mammary gland.Reproductive toxicology (Elmsford, N.Y.) · 2022Review
- Article
- Exposure to Propylparaben During Pregnancy and Lactation Induces Long-Term Alterations to the Mammary Gland in Mice.Endocrinology · 2021Article
- Update on the Health Effects of Bisphenol A: Overwhelming Evidence of Harm.Endocrinology · 2021Review
- Pregnancy-specific physiologically-based toxicokinetic models for bisphenol A and bisphenol S.Environment international · 2021Article
- Baicalin Promotes Mammary Gland Development via Steroid-Like Activities.Frontiers in cell and developmental biology · 2021Article
- Hepatic transcriptome and DNA methylation patterns following perinatal and chronic BPS exposure in male mice.BMC genomics · 2020Article
- Insights into the interactions of bisphenol and phthalate compounds with unamended and carnitine-amended montmorillonite clays.Computers & chemical engineering · 2020Article
- Endocrine-disrupting chemicals and breastfeeding duration: a review.Current opinion in endocrinology, diabetes, and obesity · 2020Review
- The Mouse Mammary Gland: a Tool to Inform Adolescents About Environmental Causes of Breast Cancer.Journal of cancer education : the official journal of the American Association for Cancer Education · 2020Article
- In utero estrogenic endocrine disruption alters the stroma to increase extracellular matrix density and mammary gland stiffness.Breast cancer research : BCR · 2020Article
- The effects of maternal exposure to BPA during pregnancy on the male reproductive system and the testicular microRNA expression profile.Environmental science and pollution research international · 2020Article
- Oestrogenic Endocrine Disruptors in the Placenta and the Fetus.International journal of molecular sciences · 2020Review
- Biochemical activity of soil contaminated with BPS, bioaugmented with a mould fungi consortium and a bacteria consortium.Environmental science and pollution research international · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Throughout life, mammary tissue is strongly influenced by hormones. Scientists have hypothesized that synthetic chemicals with hormonal activities could disrupt mammary gland development and contribute to breast diseases and dysfunction. Bisphenol S (BPS) is an estrogenic compound used in many consumer products. In this study, CD-1 mice were exposed to BPS (2 or 200 μg/kg/day) during pregnancy and lactation. Mice exposed to 0.01 or 1 μg/kg/day ethinyl estradiol (EE2), a pharmaceutical estrogen, were also evaluated. Mammary glands from female offspring were collected prior to the onset of puberty, during puberty, and in early adulthood. Growth parameters, histopathology, cell proliferation and expression of hormone receptors were quantified. Our evaluations revealed age- and dose-specific effects of BPS that were different from the effects of EE2, and distinct from the effects of BPA that have been reported previously. These assessments suggest that individual xenoestrogens may have unique effects on this sensitive tissue.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.