ArticleCurrent biology : CB2018
Memory Consolidation Is Linked to Spindle-Mediated Information Processing during Sleep.
Article in Current biology : CB, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 153 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Emergence of Abstract Structure Knowledge Across Learning and Sleep
Learning Novel Structure Across Time and Sleep
Who cites it
153 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Promoting memory consolidation during sleep: A meta-analysis of targeted memory reactivation.Psychological bulletin · 2020Pooled it
- Efficacy and mechanisms of repeated closed-loop auditory exposure during slow-wave sleep for internet gaming disorder.Molecular psychiatry · 2025Trial
- Sleep loss disrupts the neural signature of successful learning.Cerebral cortex (New York, N.Y. : 1991) · 2023Trial
- The effect of zolpidem on targeted memory reactivation during sleep.Learning & memory (Cold Spring Harbor, N.Y.) · 2021Trial
- Trial
- Sleep EEG oscillations and synaptic plasticity in memory consolidation across NREM and REM sleep.Dialogues in clinical neuroscience · 2027Review
- Odor-Cued Targeted Reactivation Was Unable to Selectively Benefit Declarative Memories During Sleep.Journal of sleep research · 2026Article
- Concurrent Presentation of Memory-Related Odours and Sounds Nullified Sleep Reactivation Benefits.Journal of sleep research · 2026Article
- Theta oscillations tag episodic memories for sleep-dependent consolidation.PLoS biology · 2026Article
- Random auditory stimulation during sleep disturbs traveling slow waves and declarative memory.iScience · 2026Article
- Longitudinal Alterations in Sleep EEG Biomarkers of Memory Consolidation in Middle-Aged and Older Adults.bioRxiv : the preprint server for biology · 2026Article
- Article
- Memory reactivation during sleep promotes structure abstraction.bioRxiv : the preprint server for biology · 2026Article
- Dream content and slow waves benefit prey against predator in a video game confrontation.Scientific reports · 2026Article
- Wakeful targeted memory reactivation during short rest periods modulates early motor learning.NPJ science of learning · 2026Article
- Implication of the thalamus in sleep alterations observed in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Memory consolidation during sleep: a facilitator of new learning?Neuropsychologia · 2026Review
- The Role of Rapid Eye Movement Sleep in Neural Differentiation of Memories in the Hippocampus.Journal of cognitive neuroscience · 2026Article
- The effects of targeted reactivation on memories cued once or multiple times during a nap.Neuropsychologia · 2025Article
- SLEEP AND NEURODEGENERATION: EXAMINING POTENTIAL PHYSIOLOGICAL MECHANISMS.Current sleep medicine reports · 2025Article
93 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
How are brief encounters transformed into lasting memories? Previous research has established the role of non-rapid eye movement (NREM) sleep, along with its electrophysiological signatures of slow oscillations (SOs) and spindles, for memory consolidation [1-4]. In related work, experimental manipulations have demonstrated that NREM sleep provides a window of opportunity to selectively strengthen particular memory traces via the delivery of auditory cues [5-10], a procedure known as targeted memory reactivation (TMR). It has remained unclear, however, whether TMR triggers the brain's endogenous consolidation mechanisms (linked to SOs and/or spindles) and whether those mechanisms in turn mediate effective processing of mnemonic information. We devised a novel paradigm in which associative memories (adjective-object and adjective-scene pairs) were selectively cued during a post-learning nap, successfully stabilizing next-day retention relative to non-cued memories. First, we found that, compared to novel control adjectives, memory cues evoked an increase in fast spindles. Critically, during the time window of cue-induced spindle activity, the memory category linked to the verbal cue (object or scene) could be reliably decoded, with the fidelity of this decoding predicting the behavioral consolidation benefits of TMR. These results provide correlative evidence for an information processing role of sleep spindles in service of memory consolidation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.