ArticleCurrent biology : CB2018
Distinct Contributions of Mesencephalic Locomotor Region Nuclei to Locomotor Control in the Freely Behaving Mouse.
Article in Current biology : CB, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
104 citing papers in PubMed, 1 synthesis or guideline pooled it, 202 citations in OpenAlex.
- Pedunculopontine Nucleus Deep Brain Stimulation Improves Gait Disorder in Parkinson's Disease: A Systematic Review and Meta-analysis.Neurochemical research · 2020Pooled it
- Using an unbiased symbolic movement representation to characterize Parkinson's disease states.Scientific reports · 2020Trial
- Redefining the central pattern generator for vertebrate locomotion.Nature reviews. Neuroscience · 2026Review
- Article
- Article
- Cuneiform Nucleus Stimulation Can Assist Gait Training to Promote Locomotor Recovery in Individuals With Incomplete Tetraplegia.Annals of neurology · 2026Article
- Activation of hypothalamic-pontine-spinal pathway promotes locomotor initiation and functional recovery after spinal cord injury in mice.Nature communications · 2025Article
- Synergistic mechanisms of medullary cholinergic-serotonergic pathway interactions in regulating neuronal excitability and locomotor activities.Communications biology · 2025Article
- Deep Brain Stimulation for Parkinson's Disease-A Narrative Review.Biomedicines · 2025Review
- Article
- The regulation of rhythmic locomotion by motor cortical and dopaminergic inputs in the mouse striatum.Molecular brain · 2025Article
- A hypothalamus-brainstem circuit governs the prioritization of safety over essential needs.Nature neuroscience · 2025Article
- Cell-type specific sensory and motor activity in the cuneiform nucleus and pedunculopontine nucleus in mice.Scientific reports · 2025Article
- Pedunculopontine-stimulation obstructs hippocampal theta rhythm and halts movement.Scientific reports · 2025Article
- Characterization of Transgenic Lines Labeling Reticulospinal Neurons in Larval Zebrafish.eNeuro · 2025Article
- Abnormal activity in the brainstem affects gait in a neuromusculoskeletal model.Journal of neuroengineering and rehabilitation · 2025Article
- Anatomical pathways and functional implications of the rodent auditory system-basal ganglia interconnectivity.Frontiers in behavioral neuroscience · 2025Review
- Motion-less depth-selective optogenetic probe using tapered fiber and an electrically tuneable liquid crystal steering element.Biomedical optics express · 2025Article
- Glutamatergic Circuits in the Pedunculopontine Nucleus Modulate Multiple Motor Functions.Neuroscience bulletin · 2024Article
- Article
44 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The mesencephalic locomotor region (MLR) has been initially identified as a supraspinal center capable of initiating and modulating locomotion. Whereas its functional contribution to locomotion has been widely documented throughout the phylogeny from the lamprey to humans, there is still debate about its exact organization. Combining kinematic and electrophysiological recordings in mouse genetics, our study reveals that glutamatergic neurons of the cuneiform nucleus initiate locomotion and induce running gaits, whereas glutamatergic and cholinergic neurons of the pedunculopontine nucleus modulate locomotor pattern and rhythm, contributing to slow-walking gaits. By initiating, modulating, and accelerating locomotion, our study identifies and characterizes distinct neuronal populations of this functional region important to locomotor command.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.